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Tim-3 promotes the ubiquitination and degradation of NF90, a novel virus sensor, and negatively regulates the NF90-SG pathway-mediated antiviral innate immunity.

Hypothalamic TTR as a novel molecular player of stress-induced long-term impact on behavior.

An integrated stem cell-based disease modeling and computational approach demonstrates how proximal airway epithelium is critical for SARS-CoV-2 infectivity and distal alveolar cells are critical for simulating the host responses.

Meningeal lymphatic vessels are present in human and nonhuman primates (common marmoset monkeys) and they can be noninvasively imaged and mapped in vivo with high-resolution, clinical MRI.

The melanoma cell interaction with lymphatic endothelial cells promotes melanoma metastasis by inducing a reversible switch to invasively sprouting melanoma cells.

t-CyCIF can be used to collect spatially-encoded, multiparametric data from fixed and embedded research or clinical specimens making it possible to probe the organization of tumors and tissues at a single-cell level.

Development of specific and high-affinity nanobodies to probe the structure of human acid sensing ion channel-1a and as binding modifiers of the toxins PcTx and MitTx1.

Ankyrin-B – through interactions with PI3P lipids, dynactin and RabGAP1L – functions as a critical node in the protein circuitry underlying polarized recycling of α5β1-integrin to enable haptotaxis along fibronectin gradients.

Characterization of PML subnuclear structures during human cytomegalovirus infection demonstrates that prolonged interferon and DNA damage signaling can induce giant PML nuclear bodies which sequentially entrap both nucleic acids and viral proteins as a cytoprotective mechanism.

Study of human, knockout mice, and in-vitro models revealed CEP78 absence is the genetical cause of cone-rod dystrophy and male infertility with multiple morphological abnormalities of sperm flagella, CEP78 interacted with IFT20 and TTC21A to modulate cilliogenesis and centriole length.