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X-ray histotomography produces the first 3-dimensional images with the combined submicron resolution, centimeter fields-of-view, soft-tissue contrast, and potential throughput to enable quantitative, histopathological and centimeter-scale phenotyping for whole-organism phenomics.

Neocortical synapses in layer 4 of the human temporal lobe neocortex were quantitatively characterized, at the subcellular level, using high-end, high-resolution electron microscopy and 3D-volume reconstructions.

Methodology to annotate the multiple origins of axonal projections in dense electron microscopy data of mammalian nervous tissue without the need of chemical label conversion is reported.

A three-dimensional investigation of extinct-tetrapod limbs shows that even though bone elongation and blood-cell production are intimately related to mammal long bones, these functions actually appeared successively in tetrapod evolution.

2D template matching enables a streamlined single-particle cryogenic electron microscopy workflow that can be used to discover new high-resolution structural features in molecules and complexes, such as bound ligands and drugs.

Each cone terminal is electrically coupled to around 50 nearby rods, forming a switchable circuit, known as the secondary rod pathway, in which all gap junction channels participate.

Ultrastructural and imaging studies of cochlear ribbon synapses demonstrate cis- and trans-synaptic molecular and structural effects in the absence of the AMPA-type glutamate receptor subunit GluA3 during mouse development in ambient sound levels.

Phase contrast X-ray tomography based on a combination of parallel and cone beam geometry extends conventional histology by a third dimension and enables full quantication of tissue remodeling in COVID-19.

A systematic high-throughput neurohistological and computational pipeline for marmoset which establishes a foundational setup in brain mapping and circuit tracing to support current and emerging research in primate studies.