3,835 results found
    1. Structural Biology and Molecular Biophysics

    ER-luminal [Ca2+] regulation of InsP3 receptor gating mediated by an ER-luminal peripheral Ca2+-binding protein

    Horia Vais et al.
    Calcium release from the endoplasmic reticulum through the IP3 receptor ion channel is strongly regulated by a calcium-binding protein in the lumen of the endoplasmic reticulum.
    1. Cell Biology

    Bmal1 integrates mitochondrial metabolism and macrophage activation

    Ryan K Alexander et al.
    Macrophage Bmal1 controls the timing of the glycolytic to oxidative metabolism transition that dictates the extent of Hif-1a activation and the associated inflammatory response.
    1. Neuroscience

    Axon-dependent expression of YAP/TAZ mediates Schwann cell remyelination but not proliferation after nerve injury

    Matthew Grove et al.
    YAP and TAZ, potent concoproteins and therapeutic targets in cancer therapy, are essential for Schwann cells to support peripheral nerve regeneration.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Conformational distributions of isolated myosin motor domains encode their mechanochemical properties

    Justin R Porter et al.
    Shifts in the balance between nucleotide-favorable and nucleotide-unfavorable conformations of myosin motors encode duty ratios and ADP release rates, demonstrating the power of an ensemble perspective for uncovering sequence-function relationships.
    1. Developmental Biology

    Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates

    Tempei Sato et al.
    Genetic analyses reveal that the loss of Lin28a causes axial shortening with mild skeletal transformations via decreased PRC1 at Hox genes, establishing a new pathway in the “Hox code.”.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Point of View: Bioengineering horizon scan 2020

    Luke Kemp et al.
    20 emerging issues in bioengineering that will have profound impacts on society have been identified.
    1. Immunology and Inflammation

    Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature

    Chao Yang et al.
    T-bet suppresses the expression of immature NK cell-defining genes.
    1. Neuroscience

    Principles of operation of a cerebellar learning circuit

    David J Herzfeld et al.
    Quantitative analysis of behavior coupled with computational modeling reveal the set of circuit-level principles that underlie cerebellar-dependent motor learning in smooth pursuit eye movements of monkeys across timescales.
    1. Chromosomes and Gene Expression

    A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans

    Kevin I Manage et al.
    SIMR-1 acts downstream of the piRNA pathway to promote siRNA amplification by the Mutator complex and localizes to perinuclear foci distinct from Mutator foci, P granules and Z granules.
    1. Neuroscience

    Effects of fluorescent glutamate indicators on neurotransmitter diffusion and uptake

    Moritz Armbruster et al.
    Fluorescent glutamate indicators distort the time course of neurotransmitter diffusion and uptake by competing with transporters, an important caveat to consider when using iGluSnFR and its analogs.

Refine your results by:

Type
Research categories