Browse the search results

Correlative imaging of the heart at multiple spatial scales has the potential to revolutionize the way we understand deficiencies in congenital heart disease.

The structure of KvAP addresses a mechanism of voltage-dependent gating that has been debated for 16 years.

Volume electron microscopy reveals the synaptic organization of the neuropil of the human hippocampal CA1 field.

The 3D structure of the six-subunit complex and its polymeric assembly gives insights into cargo transport in cilia and how specific mutations in these genes lead to ciliopathy birth defects.

A detailed molecular mechanism on lipid flipping from outside leaflet to the inside leaflet of the eukaryotic plasma membrane bilayer.

Fiducial-less tomography on single particle cryoEM samples reveals that most particles are adsorbed to the air-water interface and allows for researchers to diagnose and solve sample, grid, ice thickness, collection, and processing issues.

Eukaryotic replisomes are strongly connected together to replicate both sister DNAs produced from a bidirectional origin.

A genetic approach documents that mitochondrial DNA moves from donor cells to recipient mtDNA-depleted cells in whole mitochondria and that this restores mitochondrial respiration and the capacity of the cells to form tumours.

A morphological characterization of Drosophila olfactory receptor neurons—conducted systematically at nanoscale resolution—yields an extensive morphometric dataset, identifies novel features of olfactory sensilla, and raises intriguing questions for how the size and shape of sensory neurons influence their function.

Cryo-EM in combination with biochemistry, flow cytometry and fluorescence microscopy reveals the activation of S1PR1 by CD69, a type II membrane protein, in cis to induce receptor internalization and thereby disrupt cellular responsiveness to S1P gradients.