Biophysical and structural studies reveal how two inhibitory antibodies targeting CSP on malaria-causing Plasmodium vivax parasites lock its intrinsically flexible repeat into predominant coiled conformations, contributing molecular details of Pv inhibition by antibodies to enable structure-based engineering of PvCSP-based vaccines.

Impaired bone microstructure and bone strength are prominent characteristics of rats with hemizygous E10-16del mutation in PLS3, and treatment with alendronate or teriparatide can improve bone mineral density and bone microstructure of this novel rat model with PLS3-related early-onset osteoporosis.

The structure of gp41with its membrane anchors highlights the flexible linkage of the transmembrane regions and the fuson peptides, which generates an asymmetric conformation, a potential target of MPER bNAbs.

A 2-year field experiment reveals that plant secondary metabolites can be harnessed to increase crop productivity through plant-soil feedbacks under agronomically realistic conditions.

Single-cell transcriptome analysis of sacral compared with vagal neural crest-derived cells in the developing chick enteric nervous system reveals both similarities and differences between these two cell populations.

3D serial electron microscopy reveals that individual dopamine axons in the nucleus accumbens contain different varicosity types based on their vesicle contents, rarely make synapses, and undergo major structural plasticity in response to cocaine.

A combination of simulations and experiments was used to discover druggable cryptic pockets in non-structural protein 1, a promising but difficult target for coronaviruses, indicating a viable drug discovery approach for otherwise undruggable targets.

Molecular, cellular, and computational analyses reveal key insights into PP2A/B55α's mechanisms of substrate recruitment and active site engagement, and facilitate identification/validation of new substrates, a step towards understanding PP2A/B55α's role in multiple cellular processes.

The protease γ-secretase generates amyloid-beta peptides using a mechanism that is driven by the stabilization of an enzyme-substrate scisson complex.

Carbonic anhydrase II features a surface proton antenna that exclusively mediates proton exchange with monocarboxylate transporters to facilitate proton-coupled lactate transport in cancer cells.