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    1. Microbiology and Infectious Disease

    Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest

    Sara Marelli, James C Williamson ... Nicholas J Matheson
    Systematic screen of HIV-1 Vif mutants identifies synthetic and naturally occurring amino acid polymorphisms separating PPP2R5 and APOBEC3 family protein depletion and uncovers the mechanism of Vif-dependent cell cycle arrest.
    1. Neuroscience

    ß-arrestin 2 germline knockout does not attenuate opioid respiratory depression

    Iris Bachmutsky, Xin Paul Wei ... Kevin Yackle
    The key mechanism for opioid-like biased agonists to provide analgesia but not respiratory depression does not involve ß-arrestin 2.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Phylodynamics of SARS-CoV-2 in France, Europe, and the world in 2020

    Romain Coppée, François Blanquart ... Antoine Bridier-Nahmias
    By producing one hundred SARS-CoV-2 phylogenetic trees for different geographical and time scales, the maximum likelihood-based phylodynamic method implemented here enabled to robustly describe SARS-CoV-2 geographic spread through France, Europe, and worldwide in 2020.
    1. Immunology and Inflammation

    Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

    Nils Landegren, Lindsey B Rosen ... Olle Kämpe
    We are writing to comment on the study by Meyer et al., 2016 on disease-ameliorating autoantibodies.
    1. Neuroscience

    Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine

    Wei Huang, Andon N Placzek ... Mauro Costa-Mattioli
    Vulnerability to cocaine addiction during adolescence depends on translational control.
    1. Neuroscience

    Mechanotransduction events at the physiological site of touch detection

    Luke H Ziolkowski, Elena O Gracheva, Sviatoslav N Bagriantsev
    A novel experimental approach reveals how mechanical force acting on the skin is converted into electrical signaling in sensory neurons to evoke the sensation of touch.
    1. Cancer Biology
    2. Epidemiology and Global Health

    Risk of second primary cancers after a diagnosis of first primary cancer: A pan-cancer analysis and Mendelian randomization study

    Xiaohao Ruan, Da Huang ... Rong Na
    A certain type of primary cancer may cause another second primary cancer which would be of clinical importance to make a personalized screening plan for certain primary cancer patients.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity

    Gunjan Arora, Geoffrey T Hart ... Eric O Long
    Red blood cells infected by the malaria parasite Plasmodium falciparum are destroyed by human natural killer cells in the presence of antibodies from people who have acquired clinical immunity to malaria.
    1. Physics of Living Systems
    2. Neuroscience

    Direct mechanical stimulation of tip links in hair cells through DNA tethers

    Aakash Basu, Samuel Lagier ... AJ Hudspeth
    The ability of hair cells to produce an electrical signal in response to a mechanical stimulus stems from tension in the elastic tip links within the bundles.
    1. Developmental Biology
    2. Evolutionary Biology

    The alternative regenerative strategy of bearded dragon unveils the key processes underlying vertebrate tooth renewal

    Lotta Salomies, Julia Eymann ... Nicolas Di-Poï
    Analysis of bearded dragon model reveals a novel tooth replacement strategy that demonstrates the critical importance of epithelial patterning, cell migration, and putative stem cell functional specialization in tissue regeneration.