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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1

    Fahad Rashid et al.
    Structure specific nucleases that act in DNA replication, repair and recombination actively mold their DNA while transforming their own structure to achieve precise cleavage of their cognate DNA and avoid the deleterious cleavage of noncognate DNA.
    1. Plant Biology
    2. Evolutionary Biology

    Herbivory-induced volatiles function as defenses increasing fitness of the native plant Nicotiana attenuata in nature

    Meredith C Schuman et al.
    A 2-year field study has demonstrated that volatile compounds produced by plants when they are attacked by herbivores act as defenses by attracting predators to the herbivores and increasing the reproduction of the plants.
    1. Evolutionary Biology

    Phenotypic plasticity as a mechanism of cave colonization and adaptation

    Helena Bilandžija et al.
    Astyanax mexicanus surface-dwelling fish exposed to complete darkness develop many traits resembling cavefish adaptations by phenotypic plasticity in a single generation.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    DDM1 and Lsh remodelers allow methylation of DNA wrapped in nucleosomes

    David B Lyons, Daniel Zilberman
    Nucleosomes and linker histones block eukaryotic cytosine methylation.
    1. Structural Biology and Molecular Biophysics

    Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis

    Chantal L Márquez et al.
    Disassembly of the HIV-1 capsid is a catastrophic process, whereby initiation and propagation can be controlled independently by molecules that bind to different features of the capsid lattice.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Synergistic assembly of human pre-spliceosomes across introns and exons

    Joerg E Braun et al.
    Viewing the dynamic interactions of individual spliceosomal subcomplexes with single pre-messenger RNA molecules reveals how nearby flanking splice sites accelerate pre-spliceosome assembly and the splicing of multi-intron pre-mRNAs.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression

    Tonya Kueck et al.
    Distinct antiviral signaling pathways, triggered by the aryl hydrocarbon receptor and Interferon-gamma, converge on CDK/cyclin repression, causing inhibition of viral DNA synthesis.
    1. Structural Biology and Molecular Biophysics

    Structural basis of phosphatidylcholine recognition by the C2–domain of cytosolic phospholipase A2α

    Yoshinori Hirano et al.
    The C2-domain of cytoplasmic phospholipase A2α is structurally designed to target PC-rich membrane regions to increase the enzymatic efficiency of the catalytic domain, which prefers PCs with polyunsaturated acyl chains.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes

    Amy W Ku et al.
    Tumor-induced myeloid-derived suppressor cells exert systemic suppression of adaptive immunity by limiting L-selectin-directed trafficking of T cells at vascular checkpoints in lymph nodes.
    1. Structural Biology and Molecular Biophysics

    Structure and dynamics underlying elementary ligand binding events in human pacemaking channels

    Marcel P Goldschen-Ohm et al.
    Single-molecule resolution of cAMP binding to the ligand binding domain of pacemaking channels in zero-mode waveguides reveals the dynamics of the distinct steps underlying both binding and isomerization of the binding domain.