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    1. Stem Cells and Regenerative Medicine

    Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians

    Jordi Solana, Manuel Irimia ... Nikolaus Rajewsky
    A conserved alternative splicing program is specific to planarian stem cells and is controlled by the highly conserved splicing factors CELF and MBNL; therefore, this mode of regulating stem cells is likely ancestral to all animals.
    1. Structural Biology and Molecular Biophysics

    Deconstruction of the Ras switching cycle through saturation mutagenesis

    Pradeep Bandaru, Neel H Shah ... John Kuriyan
    Sequence conservation in Ras depends strongly on the biochemical network in which it operates, providing a framework for understanding the origin of global selection pressures on proteins.