4,526 results found
    1. Biochemistry
    2. Biophysics and Structural Biology

    A conserved MCM single-stranded DNA binding element is essential for replication initiation

    Clifford A Froelich et al
    The crystal structure of the MCM helicase bound to single-stranded DNA reveals a binding motif that is critical for cell viability, helicase activation and DNA replication.
    Research Article
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    1. Cell Biology
    2. Human Biology and Medicine

    A critical role for mTORC1 in erythropoiesis and anemia

    Zachary A Knight et al
    Transcription profiling of activated cells using Phospho-Trap, a new method for identifying activated cells, reveals a critical role for mTOR signaling in red blood cell development and the pathogenesis of anemia
    Research Article Updated
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    1. Biophysics and Structural Biology
    2. Cell Biology

    A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics

    Elisabeth A Geyer et al
    A buried mutation in αβ-tubulin reveals an allosteric response to GDP in the lattice that dictates microtubule catastrophe and shrinking.
    Research Article Updated
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    1. Immunology
    2. Microbiology and Infectious Disease

    A model symbiosis reveals a role for sheathed-flagellum rotation in the release of immunogenic lipopolysaccharide

    Caitlin A Brennan et al
    Both beneficial and pathogenic bacteria can use their sheathed flagella during host colonization as a novel toxin-/signal-delivery mechanism.
    Research Article
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    1. Developmental Biology and Stem Cells
    2. Genomics and Evolutionary Biology

    A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes

    Michelle A Carmell et al
    GCNA proteins comprise a previously unnoticed family of proteins that has been enriched in cells carrying a heritable genome since the invention of sexual reproduction in eukaryotes, and has had reproductive function for at least 600 million years.
    Research Article Updated
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    1. Biophysics and Structural Biology
    2. Developmental Biology and Stem Cells

    Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio

    Chase A Weidmann et al
    Crystal structures of Nanos bound to Pumilio and target RNAs demonstrate how Nanos forms a molecular clamp to alter Pumilio RNA regulation and specificity in embryonic development and germline maintenance.
    Research Article Updated
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    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice

    Stephanie A Bucks et al
    Cell fate-mapping with genetically-modified mouse models and cellular markers demonstrates that sensory hair cells in the vestibular portion of the inner ear are a dynamic population in adult mice that undergo cell death and replacement under normal conditions.
    Research Article
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    1. Biochemistry
    2. Biophysics and Structural Biology

    Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog

    Oleg A Volkov et al
    A catalytically dead paralog activates its cognate enzyme through an allosteric mechanism that combined structural and phylogenomic analysis indicates arose through acquisition of a dimerization domain, suggesting a general model for how complex allostery evolves.
    Research Article Updated
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    1. Biochemistry
    2. Biophysics and Structural Biology

    Structure of a AAA+ unfoldase in the process of unfolding substrate

    Zev A Ripstein et al
    The structure of a substrate-engaged AAA+ unfoldase suggests a model for processive unfolding that is supported by biochemical data.
    Research Article Updated
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    1. Biophysics and Structural Biology
    2. Plant Biology

    Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor

    A Maqbool et al
    Structure/function studies of a plant pathogen effector in complex with a host disease resistance protein domain reveal the molecular basis for recognition and underpin future engineering of immunity in crops.
    Research Article
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