43 results found
    1. Developmental Biology
    2. Neuroscience

    Sequential addition of neuronal stem cell temporal cohorts generates a feed-forward circuit in the Drosophila larval nerve cord

    Yi-wen Wang, Chris C Wreden ... Ellie Heckscher
    A newly identified pattern of circuit assembly shows connectivity between small groups of neurons born in tight time windows from different stem cells, with outputs from one lineage born before inputs from other lineages.
    1. Developmental Biology
    2. Neuroscience

    Regulation of subcellular dendritic synapse specificity by axon guidance cues

    Emily C Sales, Emily L Heckman ... Chris Q Doe
    Axon guidance cues restrict sensory neuron synapse formation to a subset of equally acceptable interneuronal dendritic arbors during Drosophila locomotor circuit assembly.
    1. Developmental Biology
    2. Neuroscience

    Presynaptic contact and activity opposingly regulate postsynaptic dendrite outgrowth

    Emily L Heckman, Chris Q Doe
    Opposing mechanisms determine dendrite arbor size during a critical period in Drosophila.
    1. Neuroscience

    Conserved neural circuit structure across Drosophila larval development revealed by comparative connectomics

    Stephan Gerhard, Ingrid Andrade ... Casey M Schneider-Mizell
    The connectivity structure of a nociceptive circuit is precisely maintained over Drosophila larval development through cell type-specific increases in synaptic contacts as measured from electron microscopy reconstructions, while individual neurons grow five-fold in size and number of synapses.
    1. Neuroscience

    Cytoarchitectonic, receptor distribution and functional connectivity analyses of the macaque frontal lobe

    Lucija Rapan, Sean Froudist-Walsh ... Nicola Palomero-Gallagher
    3D atlas of the macaque frontal lobe, based on the novel quantitative parcellation, integrates anatomical, neurochemical, and functional connectivity data.
    1. Neuroscience

    Balance of activity during a critical period tunes a developing network

    Iain Hunter, Bramwell Coulson ... Richard A Baines
    Neurodevelopmental critical periods act to integrate activity to encode homeostatic set points that remain fixed thereafter.
    1. Neuroscience

    Nociceptive interneurons control modular motor pathways to promote escape behavior in Drosophila

    Anita Burgos, Ken Honjo ... Wesley B Grueber
    A class of interneuron is identified that promotes escape behavior downstream of nociceptor inputs via connections to nociceptive integrator and premotor networks.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Meiotic drive of female-inherited supernumerary chromosomes in a pathogenic fungus

    Michael Habig, Gert HJ Kema, Eva Holtgrewe Stukenbrock
    Female-inherited supernumerary chromosomes that lack a male-inherited homolog are transmitted to all meiotic products instead of the expected half, which indicates an additional amplification of unpaired chromosomes during meiosis.
    1. Neuroscience

    Neural substrates of cold nociception in Drosophila larva

    Atit A. Patel, Albert Cardona, Daniel N. Cox
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    • Incomplete
    1. Biochemistry and Chemical Biology

    An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

    Tim Aguirre, Gillian L Dornan ... Dorothea Fiedler
    A subtle mutation in the ATP-binding site of inositol hexakisphosphate kinases increases their conformational flexibility and thereby makes them susceptible to isozyme-selective, allosteric inhibition.

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