Opioids cause hyperpolarization and pre-synaptic suppression among a subset of preBötzinger Complex neurons to impair respiratory rhythmogenesis.

A combination of unbiased scRNA-sequencing and functional approaches in organoid cultures and injury-repair models in vivo reveals major heterogeneity in adult murine airway basal cells, which is established prenatally and conserved in humans.

The transcriptional response of human neurons to calcium ion signals shows evolutionary divergence from those responses elicited in mouse neurons, providing evidence in favour of using human systems to study neuronal responses to external stimuli.

Male and female mice react differently to social isolation but not to an acute physical stress.

Estrogen increases hypothalamic arcuate kisspeptin neuronal excitability and glutamate release to coordinate autonomic functions for maximizing reproductive success.

Improved chemical, molecular biology, and computational approaches establish an optimized method for accurate and precise quantification of tRNA expression, modifications, and aminoacylation.

Hippocampal area CA2 controls low gamma and ripple oscillations, brain waves known to be impaired in schizophrenia, implicating this important brain region in cognition.

Two new polymorphic structures of recombinant human alpha-synuclein fibrils show striking differences to previous structures, while familial PD mutation sites remain crucial for protofilament interaction and fibril stability.

Knockout of Terc impedes effective immune defense against bacterial lung infections in mice, exacerbating disease course and revealing the critical function of Terc in pulmonary immunity.

Fish environmental DNA remaining in a cup of seawater provides information about interaction strengths among marine fish species in nature, highlighting the potential impact of global climate change on community dynamics and stability.