120 results found
    1. Cell Biology

    Chemotherapy resistance due to epithelial-to-mesenchymal transition is caused by abnormal lipid metabolic balance

    Atsushi Matsumoto, Akihito Inoko ... Junichi Ikenouchi
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Microbiology and Infectious Disease

    Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis

    Nelson V Simwela, Eleni Jaecklein ... David G Russell
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology
    2. Neuroscience

    Key epigenetic and signaling factors in the formation and maintenance of the blood-brain barrier

    Jayanarayanan Sadanandan, Sithara Thomas ... Peeyush Kumar T
    Histone deacetylase 2 (HDAC2) and polycomb repressive complex 2 (PRC2) control endothelial gene expression for BBB development and prevented Wnt/β-catenin target genes from being expressed in adult CNS ECs.
    1. Immunology and Inflammation

    Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice

    Ning Song, Hang Gao ... Wenlong Zhang
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Incomplete
    1. Neuroscience

    Integration of overlapping sequences emerges with consolidation through medial prefrontal cortex neural ensembles and hippocampal–cortical connectivity

    Alexa Tompary, Lila Davachi
    Changes in cortical neural ensembles and heightened coupling between the hippocampus and cortex enable the eventual behavioral integration of memories with overlapping sequential information.
    1. Cell Biology

    Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity

    Dan Wu, Venkateswararao Eeda ... Weidong Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    Host-derived Lactobacillus plantarum alleviates hyperuricemia by improving gut microbial community and hydrolase-mediated degradation of purine nucleosides

    Yang Fu, Xiao-Dan Luo ... Wence Wang
    Lactobacillus plantarum regulates host uric acid metabolism via its own nucleoside hydrolase iunH.
    1. Genetics and Genomics

    Perturbations in eIF3 subunit stoichiometry alter expression of ribosomal proteins and key components of the MAPK signaling pathways

    Anna Herrmannová, Jan Jelínek ... Leoš Shivaya Valášek
    eIF3, despite being a general translation initiation factor, functions in mRNA-specific regulation, having a profound impact on the synthesis and activation of the MAPK pathway components and ribosomal proteins.
    1. Immunology and Inflammation

    Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

    Valentina Stolz, Rafael de Freitas e Silva ... Wilfried Ellmeier
    The transcriptional adapter protein NCOR1 that links chromatin-modifying enzymes with gene-specific transcription factors controls naive and effector regulatory T cell states.
    1. Immunology and Inflammation
    2. Neuroscience

    Transcriptional responses in a mouse model of silicone wire embolization induced acute retinal artery ischemia and reperfusion

    Yuedan Wang, Ying Li ... Xuan Xiao
    The UPOAO model effectively replicates retinal ischemia in retinal artery occlusion, providing a novel platform for identifying pathogenic genes and advancing therapeutic research.
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