7,333 results found
    1. Epidemiology and Global Health

    Mortality: The challenges of estimating biological age

    Alexey Moskalev
    A comparison of nine different approaches over a period of 20 years reveals the most promising indicators for biological age.
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    1. Computational and Systems Biology

    Research: Bias in the reporting of sex and age in biomedical research on mouse models

    Oscar Flórez-Vargas et al.
    A text-mining study suggests that about half of the papers reporting the results of experiments on mice do not report the sex and age of the mice.
    1. Stem Cells and Regenerative Medicine

    Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration

    Takashi Baba et al.
    The IL-4/IL-4Rα axis directory promotes pathological angiogenesis through communications with bone marrow cells leading to neovascular age-related macular degeneration.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

    Ioanna Oikonomidi et al.
    Secretion of the inflammatory cytokine TNF requires a protein called iTAP/FrmD8, which controls the cell surface stability of the TNF shedding machinery, iRhom2 and TACE/ADAM17.
    1. Neuroscience

    A causal relationship between face-patch activity and face-detection behavior

    Srivatsun Sadagopan et al.
    Disrupting the activity of the medial lateral face patch (ML) using fMRI-targeted microinjections of muscimol leads to anatomically and categorically specific impairments in a naturalistic face detection task.
    1. Medicine

    Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients

    Gian Paolo Rossi et al.
    Current evidence does not suggest adverse effects of ACE inhibitors or ARBs in COVID-19 patients and, to the contrary, discontinuing these drugs in these patients may potentially be harmful.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

    Adam Graham Grieve et al.
    The iRhom2 protein, a catalytically inactive relative of rhomboid proteases, controls inflammation and growth factor signalling by acting as an essential multifunctional regulatory subunit of the cell surface shedding protease TACE (ADAM17).
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Sister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect

    Agata P Zielinska et al.
    Multiple age-related changes in chromosome architecture could explain why human oocyte aneuploidy increases with advanced maternal age.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Plasmodium-specific atypical memory B cells are short-lived activated B cells

    Damián Pérez-Mazliah et al.
    Plasmodium-specific atypical memory B cells generated to naturally (mosquito) transmitted rodent malaria infection are short-lived activated B cells, and do not prevent resolution of infection or generation of long-lived memory.
    1. Neuroscience

    Neural dynamics at successive stages of the ventral visual stream are consistent with hierarchical error signals

    Elias B Issa et al.
    Neural spiking responses in the visual cortex carry both an explicit representation of the presence of a face and a late-arriving, explicit encoding of errors in face estimation.

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