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    1. Medicine

    Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2

    Mohammad Afsar, Rohan Narayan ... Tanweer Hussain
    Drug targeting Nsp1-ribosome interaction shows rescue of Nsp1-mediated translation inhibition and has antiviral activity against SARS-CoV-2.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles

    Xu Zheng, Shi Yu ... Guangxun Meng
    Interleukin-1 activates RhoA/ROCK signaling, which drives the enrichment of actin bundles at the cell-cell junctions, preventing SARS-CoV-2 spreading via syncytia formation.
    1. Medicine

    Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral–bacterial interactions

    Ilja L Kruglikov, Manasi Shah, Philipp E Scherer
    Dysfunctionaladipose tissue puts obese and type 2 diabetic patients at higher risk.
    1. Immunology and Inflammation

    ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

    Riem Gawish, Philipp Starkl ... Sylvia Knapp
    Only three Spike mutations enable murine SARS-CoV-2 infection, which is still strictly ACE2 dependent and causes a COVID-19-like disease in mice with immunopathology-driven lung damage.
    1. Developmental Biology
    2. Genetics and Genomics

    Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes

    Allen Wang, Joshua Chiou ... NHLBI LungMap Consortium
    Generation of a human lung single nucleus ATAC-seq and single nucleus RNA-seq datasets reveals candidate cis-regulatory elements that advance knowledge on gene expression control in normal and diseased lungs.
    1. Immunology and Inflammation

    Murine alveolar macrophages rapidly accumulate intranasally administered SARS-CoV-2 Spike protein leading to neutrophil recruitment and damage

    Chung Park, Il-Young Hwang ... John H Kehrl
    The SARS-CoV-2 Spike proteins demonstrate in vivo cellular tropism, ascertain targets within human mononuclear cells, and provide insights into their functional consequences, thereby enhancing comprehension of their impact on humans.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease

    Kejia Zhang, Patrick Eldin ... Dragony Fu
    SARS-CoV-2 infection reduces the intracellular levels of a human tRNA modification enzyme and alters host tRNA modification profiles.
    1. Microbiology and Infectious Disease

    Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms

    Mie Suzuki Okutani, Shinya Okamura ... Hirotaka Ebina
    The novel live-attenuated SARS-CoV-2 nasal vaccine candidate is highly safe, induces robust cellular and mucosal immunity, and generates long-lasting neutralizing antibody titers.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals

    Evelyn Jagoda, Davide Marnetto ... Terence D Capellini
    Key functional variants, discovered using Massively Parallel Reporter Assay (MPRA) and reporter assays in the context of SARS-CoV-2 infection, support the importance of two critical chemokine receptor genes CCR1 and CCR5 in severe Covid-19 illness.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences

    Jeffrey Y Lee, Peter AC Wing ... Ilan Davis
    Single-molecule analysis of SARS-CoV-2 RNA identifies significant heterogeneity in cellular viral RNA levels and highlights slower replication kinetics for the Alpha variant compared to the Victoria strain.
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