16 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

    Anassuya Ramachandran et al.
    SMAD1/5 signaling is essential for the full transforming growth factor β (TGF-β)-induced transcriptional program and physiological responses and is induced via a novel receptor activation mechanism, involving two distinct type I receptors.
    1. Chromosomes and Gene Expression

    Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling

    Davide M Coda et al.
    NODAL/Activin-induced SMAD2 binding directly drives remodeling of both open and closed chromatin and does not directly correlate with temporal patterns of gene expression upon prolonged signaling.
    1. Plant Biology

    Pathogen effectors and plant immunity determine specialization of the blast fungus to rice subspecies

    Jingjing Liao et al.
    Specialized fungal pathogen populations infect rice varieties with contrasting immune systems co-cultivated in a traditional agro-system, indicating the relevance of crop diversity to restricting epidemics in the landscape.
    1. Developmental Biology

    Maternal Gdf3 is an obligatory cofactor in Nodal signaling for embryonic axis formation in zebrafish

    Brent W Bisgrove et al.
    Maternal Gdf3 and Nodal are interdependent obligatory cofactors in the fundamental patterning of the vertebrate embryonic axis of zebrafish.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation

    Ceri A Fielding et al.
    The human cytomegalovirus US12 gene family work co-operatively to degrade large numbers of immune ligands and prevent recognition by natural killer cells.
    1. Human Biology and Medicine

    Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity

    Tingqing Guo et al.
    The ALK7 receptor functions cell-autonomously and homeostatically in adult adipocytes to regulate catecholamine sensitivity in response to the diet.
    1. Neuroscience

    Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss

    Fredrick E Henry et al.
    Cell type-specific transcriptomics in energy homeostasis neurons has identified hundreds of genes and multiple signaling pathways that are regulated by weight loss in mice, as well as several previously unexamined genes that can regulate appetite and body weight.
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor

    A Maqbool et al.
    Structure/function studies of a plant pathogen effector in complex with a host disease resistance protein domain reveal the molecular basis for recognition and underpin future engineering of immunity in crops.
    1. Developmental Biology
    2. Neuroscience

    BMPs direct sensory interneuron identity in the developing spinal cord using signal-specific not morphogenic activities

    Madeline G Andrews et al.
    Members of the BMP family of growth factors act as a reiterative code of distinct activities to direct the identities of different classes of sensory neurons in the spinal cord.

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