Height in early adulthood is an indicator that integrates across different dimensions of sustainable human development with links to health and longevity, nutrition, education and economic productivity.
Joshua S Talboom, Asta Håberg ... Matthew J Huentelman
An internet-based cohort study of paired associate learning shows that a first-degree family history of dementia is associated with lowered performance, an effect modified by apolipoprotein E genotype and diabetes.
Andrea Strakova, Máire Ní Leathlobhair ... Elizabeth P Murchison
Genetics of a canine transmissible tumour show how the world’s oldest cancer “metastasised” through the global dog population – and captured, maintained and rearranged its mitochondrial DNA along the way.
A biochemical approach unveils the overall shape of a subclass of heavy-metal transporting pumps, thereby shedding light on principle molecular determinants linked to the transport mechanism of these elusive machines, information that is critical well beyond basic science.
Hui Zhen Tan, Justin JFJ Jansen ... Frank E Rheindt
Application of museomics facilitates characterization of the contribution of historical factors to genetic diversity declines in Numenius shorebirds and highlights that extinction of ecosystem-engineering megafauna may have been detrimental for open-landscape species.
Dawn M Wenzel, Douglas R Mackay ... Wesley I Sundquist
A comprehensive, quantitative, protein-protein interaction screen maps the network of interactions between human MIT domains and ESCRT-III C-terminal tails, and reveals MIT domain-containing protein cofactors for abscission and the 'No Cut' abscission checkpoint.
TGN46 is a cargo receptor, with its luminal domain being necessary and sufficient to load soluble secretory proteins into transport carriers for export out of the trans-Golgi network.
Increasing semantic relationships with old information accelerates learning and enhances memory for new information and increases the likelihood of both old and new information being recalled together.
