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    1. Cancer Biology
    2. Cell Biology

    Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer

    Christina R Adams, Htet Htwe Htwe ... Rushika M Perera
    The GLI2 transcription factor is a master regulator of the aggressive basal-like subtype of pancreatic cancer and enables adaptation to oncogenic KRAS ablation.
    1. Microbiology and Infectious Disease

    Regulatory roles of Escherichia coli 5' UTR and ORF-internal RNAs detected by 3' end mapping

    Philip P Adams, Gabriele Baniulyte ... Joseph T Wade
    Multiple RNA-seq approaches globally mapped RNA 3´ ends resulting in the discovery of numerous and diverse RNA regulators.
    1. Neuroscience

    A double dissociation between semantic and spatial cognition in visual to default network pathways

    Tirso RJ Gonzalez Alam, Katya Krieger-Redwood ... Elizabeth Jefferies
    Default mode network and visual cortex are connected via two parallel pathways that differentially respond to the processing of visual scenes and semantic information about objects, reflecting domain-specific organisation.
    1. Developmental Biology

    TALE factors use two distinct functional modes to control an essential zebrafish gene expression program

    Franck Ladam, William Stanney ... Charles G Sagerström
    TALE transcription factors bind different genomic motifs and function together with different protein partners at different stages of zebrafish embryogenesis.
    1. Cell Biology

    Quantitative glycoproteomics reveals cellular substrate selectivity of the ER protein quality control sensors UGGT1 and UGGT2

    Benjamin M Adams, Nathan P Canniff ... Daniel N Hebert
    Natural substrates of the central endoplasmic reticulum quality control glycoprotein sensors UDP-glucose:glycoproteinglucosyltransferase (UGGT)1 and UGGT2 were identified using a glycoproteomics approach and the role for their modification was explored.
    1. Neuroscience

    An open-source platform for head-fixed operant and consummatory behavior

    Adam Gordon-Fennell, Joumana M Barbakh ... Garret D Stuber
    A customizable open-source hardware and software platform for conducting diverse behavioral experiments in head-fixed mice.
    1. Neuroscience

    Open-source, Python-based, hardware and software for controlling behavioural neuroscience experiments

    Thomas Akam, Andy Lustig ... Mark E Walton
    pyControl is an open-source tool that makes it easy to specify complex behavioural tasks, run them at scale on low-cost hardware, and communicate task logic to other researchers.
    1. Cancer Biology

    MPDZ promotes DLL4-induced Notch signaling during angiogenesis

    Fabian Tetzlaff, M Gordian Adam ... Andreas Fischer
    The multiple PDZ domain protein recruits Notch ligands to Nectin-2, which increases Notch signaling activity during angiogenesis.
    1. Cell Biology
    2. Developmental Biology

    Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation

    Jaclyn Camuglia, Soline Chanet, Adam C Martin
    Morphogenetic forces from tissue invagination orient cell division through a previously undescribed mechanism of force-dependent LGN/Pins polarization.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Diminishing neuronal acidification by channelrhodopsins with low proton conduction

    Rebecca Frank Hayward, F Phil Brooks III ... Adam E Cohen
    Many channelrhodopsins acidify cells, but two new ones do not.