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    1. Evolutionary Biology
    2. Genetics and Genomics

    On the limits of fitting complex models of population history to f-statistics

    Robert Maier, Pavel Flegontov ... David Reich
    Many published findings about population history that rely on inference of admixture graph models fitted to f-statistics are not robust since the method is generally inappropriate for extracting new information about population history.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A bacterial membrane sculpting protein with BAR domain-like activity

    Daniel A Phillips, Lori A Zacharoff ... Sarah M Glaven
    Uniform diameter and curvature of the outer membrane extensions and vesicles of Shewanella oneidensis are maintained by a bacterial Bin/Amphiphysin/Rvs (BAR) domain-like protein BdpA.
    1. Neuroscience

    The Neurodata Without Borders ecosystem for neurophysiological data science

    Oliver Rübel, Andrew Tritt ... Kristofer E Bouchard
    The NWB data language enables reproduction, interchange, and reuse of diverse neurophysiology data, and the design principles of NWB are generally applicable to enhance discovery across biology through data FAIRness.
    1. Neuroscience

    Chronically implanted Neuropixels probes enable high-yield recordings in freely moving mice

    Ashley L Juavinett, George Bekheet, Anne K Churchland
    A new device enables researchers to use and recycle extracellular electrodes (e.g. Neuropixels) for high-yield recordings during freely moving mouse experiments.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    HP1 proteins compact DNA into mechanically and positionally stable phase separated domains

    Madeline M Keenen, David Brown ... Sy Redding
    Heterochromatin proteins compartmentalize DNA into compact structures resistant to mechanical disruption but susceptible to competitive dissolution.
    1. Biochemistry and Chemical Biology

    Syntaxin-6 delays prion protein fibril formation and prolongs the presence of toxic aggregation intermediates

    Daljit Sangar, Elizabeth Hill ... Jan Bieschke
    A new native prion protein aggregation assay shows that syntaxin-6, a risk factor for sporadic Creutzfeldt–Jakob disease, delays prion protein fibril formation and prolongs the presence of toxic aggregation intermediates.
    1. Genetics and Genomics
    2. Plant Biology

    Epigenetic silencing of a multifunctional plant stress regulator

    Mark Zander, Björn C Willige ... Joseph R Ecker
    Interplay between histone demethylation and chromatin remodeling shapes the chromatin environment of the essential stress regulator ETHYLENE-INSENSITIVE2.
    1. Neuroscience

    Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics

    Yoshinori Aso, Robert P Ray ... Gerald M Rubin
    The interplay of nitric oxide and dopamine specialize one memory unit in a fly brain in predicting the value of odors based only on recent experience.
    1. Ecology

    Role of immigrant males and muzzle contacts in the uptake of a novel food by wild vervet monkeys

    Pooja Dongre, Gaëlle Lanté ... Erica van de Waal
    New immigrants triggered fast uptake of a novel food in groupmates, who obtained information about it through muzzle contacts, opening up new questions about the role of dispersers in information flow around a population.
    1. Cell Biology

    Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions

    Florian Geisler, Sanne Remmelzwaal ... Rudolf E Leube
    Aberrant cytoskeletal intermediate filament networks in the C. elegans intestine are associated with hyperphosphorylated intermediate filament proteins and impact not only intestinal cell structure but have also detrimental consequences for organismal well-being.