The ALK7 receptor functions cell-autonomously and homeostatically in adult adipocytes to regulate catecholamine sensitivity in response to the diet.

The first example of an animal where RNA-editing dramatically reshapes the entire proteome demonstrates that editing must be a critical evolutionary and adaptive force.

Use of a newly developed experimental model in fruit flies reveals that death following traumatic brain injury is largely due to a mechanism by which brain damage triggers disruption of the intestinal barrier, leading to elevated levels of glucose in the circulatory system with deleterious consequences.

Pain sensation induces relapse in a mouse model of multiple sclerosis via a sensory-sympathetic signaling pathway.

Fish trace amine-associated receptors evolved a novel structural motif that enables the detection of chemically diverse amine odors in a non-canonical 'inverted' orientation.

Heterotrimeric G proteins are coupled to and regulate plant receptor signaling, which allows optimum immune activation and enhances the production of reactive oxygen species.

Proper gut health depends on the balance between two naturally occurring variants of a transcription factor in the colon.

Epithelial tumors secrete the ER-resident AGR2 in the extracellular matrix to function as a novel essential microenvironmental regulator of epithelial tissue architecture, which leads to tumorigenicity.

A new purification method for stereocilia membranes enables efficient immunoaffinity purification of rare protein complexes from hair cell stereocilia, including the newly described complex of deafness genes PDZD7 and MYO7A.

The C9orf72 expansion binds and sequesters the splicing factor hnRNP H leading to insoluble G-quadruplex aggregates that functionally reduce hnRNP H, thereby producing splicing defects.