59 results found
    1. Cell Biology
    2. Plant Biology

    Members of the ELMOD protein family specify formation of distinct aperture domains on the Arabidopsis pollen surface

    Yuan Zhou et al.
    Pollen aperture patterning in Arabidopsis is controlled by members of the ELMOD protein family, whose expression levels in developing pollen lineage are tightly regulated.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

    Luka Bacic et al.
    Analysis of conformational heterogeneity in cryo-EM data by a recently developed deep learning method reveals the structure and dynamics of the oncogenic chromatin remodeler ALC1 bound to a poly-ADP-ribosylated nucleosome.
    1. Cell Biology
    2. Developmental Biology

    GIV/Girdin, a non-receptor modulator for Gαi/s, regulates spatiotemporal signaling during sperm capacitation and is required for male fertility

    Sequoyah Reynoso et al.
    Spermatozoa require GIV for specialized compartmentalized signaling to support efficient capacitation while inhibiting premature acrosome reaction.
    1. Developmental Biology
    2. Neuroscience

    R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners

    Jessica Douthit et al.
    R7 photoreceptors require the endosomal protein Lost and Found to form stable connections only when this protein is also present in neurons that are synaptic partners of R7.
    1. Developmental Biology

    Ongoing repair of migration-coupled DNA damage allows planarian adult stem cells to reach wound sites

    Sounak Sahu et al.
    Adult stem cells acquire increased DNA damage as they migrate to a wound site and require active DNA repair mechanisms for normal migration.
    1. Biochemistry and Chemical Biology

    HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase

    Johannes Rudolph et al.
    The polymerase activity of PARP1 is converted to hydrolase activity upon binding of Histone Parylation Factor 1 (HPF1) with nucleosome activators.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    NAD+ enhances ribitol and ribose rescue of α-dystroglycan functional glycosylation in human FKRP-mutant myotubes

    Carolina Ortiz-Cordero et al.
    The combined use of NAD+ with ribitol or ribose potentiates the rescue of α-dystroglycan functional glycosylation in FKRP-mutant patient-specific iPSC-derived myotubes, representing potential novel treatments for FKRP muscular dystrophies.
    1. Biochemistry and Chemical Biology

    Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets

    Kelsie M Rodriguez et al.
    A combined chemical genetics, proximity labeling, and ADP-ribose site mapping approach shows that PARP-7 mono-ADP-ribosylates immune-relevant proteins on cysteine amino acids.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells

    Lavanya H Palavalli Parsons et al.
    PARP-7 is a mono(ADP-ribosyl) transferase that directs an extensive ADP-ribosylated proteome to control microtubule stability, and regulate ovarian cancer cell growth and motility.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ARL3 activation requires the co-GEF BART and effector-mediated turnover

    Yasmin ElMaghloob et al.
    BART is a co-GEF for ARL3 and maintains the active ARL3-GTP until it is recycled by ARL3 effectors.

Refine your results by:

Type
Research categories