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    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation

    Charles E MacKay, Miranda Floen ... Jonathan H Jaggar
    Flow stimulates PC-1/PC-2 clusters in the plasma membrane of endothelial cells, leading to Ca2+ influx, NOS, SK channel, and IK channel activation, vasodilation, and a reduction in blood pressure.
    1. Neuroscience
    2. Physics of Living Systems

    Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure

    Simon Bulley, Carlos Fernández-Peña ... Jonathan H Jaggar
    Arterial myocyte PKD2 channels are activated by vasoconstrictor stimuli, which increases blood pressure, are upregulated during hypertension and cell-specific knockout in vivo reduces both physiological blood pressure and hypertension.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis

    Janani Gopalan, Mitchell H Omar ... John D Scott
    An anchored phosphatase-deacetylase complex participates in primary cilia development.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium

    Xiaowen Liu, Thuy Vien ... David E Clapham
    The primary cilia polycystin proteins, polycystin-1 and polycystin-2, affect cilia length in the kidney collecting duct epithelia, but only polycystin-2 is required for the functional ion channel in this organelle.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus

    Kotdaji Ha, Mai Nobuhara ... Markus Delling
    Soluble fragments cleaved from the N-terminus of PC-1 activate the PC-1/PC-2 heteromeric polycystin channel, describing for the first time that the N-terminus itself is an endogenous ligand.
    1. Structural Biology and Molecular Biophysics

    Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists

    Shristi Pawnikar, Brenda S Magenheimer ... Yinglong Miao
    Structural dynamic insights revealed the mechanisms of PC1 activation by stalk-derived peptide agonists which can form a foundation for development of PC1 as a therapeutic target for ADPKD treatment.
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