Origin recognition complex-associated (ORCA) is crucial for the stability of the Histone H3 lysine 9 methyltransferase megacomplex, which is essential for heterochromatin organization.

Epigenetic clocks are an accurate measure of biological aging and 'tick' slower in male sheep that are castrated.

DNA sequences from the Middle Pleistocene reveal that the extinct Eurasian straight-tusked elephants were closely related to today's African forest elephants (Loxodonta cyclotis) in Africa.

Body shape and behavioural specializations found across the castes of ant species evolved together and reflect different abilities for ground behaviors.

Interleukin 4 signaling co-opts the Akt-mTORC1-Acly pathway to couple metabolic input to the control of energetically demanding processes during macrophage M2 activation.

Akt phosphorylates insulin receptor substrate to engage negative feedback and limit signal propagation.

A signalling cascade involving PI3K/Akt1 remodels the extra-cellular matrix to achieve atypical cellular responses and control cell fate specification within the embryonic endoderm.

Cavin-3 is a tumor suppressor protein that inhibits Akt signaling, suppresses Warburg metabolism, promotes apoptosis, and protects against cachexia.

The PBAF chromatin-remodelling complex is essential for the proliferation of melanocytes and melanoma cells and is recruited to critical regulatory elements by physical and functional interactions with MITF, a transcription factor and master regulator of melanoma.

A chemically unstable ostrich eggshell peptide survives for at least 3.8 million years at the equator, stabilized by strong mineral interactions.