7,579 results found
    1. Cancer Biology

    Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models

    Hui Qin Wang et al.
    The combination of ceritinib with CGM097 demonstrates remarkable antitumor activity in TP53 wild-type neuroblastoma models with ALK aberrations and is able to overcome the resistance acquired during ceritinib treatment.
    1. Cell Biology
    2. Neuroscience

    A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis

    Brittany M Edens et al.
    A novel ALS-associated variant in UBQLN4 impairs proteasome function and beta-catenin degradation to drive aberrant axon morphogenesis in motor neurons.
    1. Plant Biology

    Glycosylphosphatidylinositol-anchored proteins as chaperones and co-receptors for FERONIA receptor kinase signaling in Arabidopsis

    Chao Li et al.
    FERONIA receptor kinase interacts with phosphatidylinositol-anchored proteins LORELEI and LLG1 to ensure its proper functional location in the cell membrane and engages them as co-receptors on the cell surface to mediate a broad spectrum of growth and signaling processes.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons

    Disi An et al.
    Stem cell-derived motor neurons with differential ALS vulnerability identified proteasome activity as a possible mechanism that explains their differential sensitivity.
    1. Evolutionary Biology

    Splicing repression allows the gradual emergence of new Alu-exons in primate evolution

    Jan Attig et al.
    During evolutionary progression of Alu-exons, repressive U-tracts buffer sudden gains in 3' splice site strength and prevent inclusion of cryptic exons.
    1. Cell Biology

    Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

    Peipei Zhang et al.
    OptoGranules reveal the function of G3BP1 as a stress granule scaffold and demonstrate that protracted stress granule assembly is sufficient to drive neurodegeneration and the evolution of ALS-FTD pathology.
  1. Research: Sci-Hub provides access to nearly all scholarly literature

    Daniel S Himmelstein et al.
    The availability of almost all articles from toll access journals in the Sci-Hub repository will disrupt scholarly publishing towards more open models.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Point of View: Hypothesis, analysis and synthesis, it's all Greek to me

    Ioannis Iliopoulos et al.
    Many scientific terms have been borrowed from ancient languages, but their modern usage often overlooks their etymology, as do many new terms coined by scientists.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1

    Haichuan Zhu et al.
    The identification of key determinants of LSC “stemness” and LSC differentiation that is reversible through an epigenetic mechanism may have considerable implications in understanding leukemia and designing effective therapies.
    1. Cell Biology
    2. Human Biology and Medicine

    Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63

    Yannick von Grabowiecki et al.
    Atrophic muscles of patients and animal models developing amyotrophic lateral sclerosis show an upregulation of TAp63 that stimulates the expression of a pro-atrophic ubiquitin ligase.

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