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    1. Neuroscience

    Egr2 induction in spiny projection neurons of the ventrolateral striatum contributes to cocaine place preference in mice

    Diptendu Mukherjee, Ben Jerry Gonzales ... Ami Citri
    The ventrolateral striatum is found to be recruited during the encoding of cocaine preference, within which Egr2-expressing ensembles are functionally important, as is the expression of Egr2 within them.
    1. Neuroscience

    Salient experiences are represented by unique transcriptional signatures in the mouse brain

    Diptendu Mukherjee, Bogna Marta Ignatowska-Jankowska ... Ami Citri
    Inducible transcription in the brain encodes detailed aspects of recent experience.
    1. Structural Biology and Molecular Biophysics

    Integrative dynamic structural biology unveils conformers essential for the oligomerization of a large GTPase

    Thomas-O Peulen, Carola S Hengstenberg ... Christian Herrmann
    Multimodal spectroscopy (smFRET, EPR, SAXS, and SANS) and integrative structural modeling reveal large-scale domain rearrangements in human guanylate binding protein 1 (hGBP1) that are driving forces for the formation of oligomers that enable its biological function in innate immune defense.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics

    Amy R Strom, Ronald J Biggs ... Andrew D Stephens
    Micromanipulation experiments demonstrate that HP1α strengthens interphase and mitotic chromosome mechanics and maintains nuclear shape by chromatin crosslinking, separate from histone methylation.
    1. Neuroscience

    Pro-social behavior in rats is modulated by social experience

    Inbal Ben-Ami Bartal, David A Rodgers ... Peggy Mason
    Rats show socially selective helping behavior based on familiarity with the type of rat, but not necessarily the individual rat.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells

    Nuria Vilaplana-Lopera, Vincent Cuminetti ... Paloma Garcia
    Interplay between AML and stromal cells can initiate a mechanism involving gap junctions where ROS is transferred from cancer cells to stromal cells which then produce acetate which can in return be absorbed/utilised by the cancer cells.
    1. Cell Biology

    Waves of actin and microtubule polymerization drive microtubule-based transport and neurite growth before single axon formation

    Amy M Winans, Sean R Collins, Tobias Meyer
    Waves of polymerizing actin work in concert with microtubule polymerization to lay down more microtubules tracks and transiently increase microtubule-based transport into the growing neurite.
    1. Developmental Biology
    2. Neuroscience

    Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons

    Catherine M Drerup, Amy L Herbert ... Alex V Nechiporuk
    Actr10, a dynactin pointed end protein, is essential for mitochondrial interaction with the dynein-dynactin retrograde motor and subsequent transport.
    1. Medicine

    The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury

    Amy Louise Ball, Carol E Jolly ... Amy E Chadwick
    HepG2 transmitochondrial cybrids of haplogroup J genome had increased sensitivity to aspects of mitochondrial dysfunction induced by tolcapone and 2-hydroxyflutamide, compared to haplogroup H, thus cybrids provide a practical system to investigate the consequences of mitochondrial genome on drug-induced hepatotoxicity.
    1. Epidemiology and Global Health

    Lives saved with vaccination for 10 pathogens across 112 countries in a pre-COVID-19 world

    Jaspreet Toor, Susy Echeverria-Londono ... Katy AM Gaythorpe
    Vaccination activities that occurred before the COVID-19 pandemic, 2000-2019, are estimated to avert 50 million deaths, highlighting the enormous benefits of continued and improving vaccination.