8,040 results found
    1. Neuroscience

    Enrichment drives emergence of functional columns and improves sensory coding in the whisker map in L2/3 of mouse S1

    Amy M LeMessurier, Keven J Laboy-Juárez ... Daniel E Feldman
    Sensory enrichment creates a more columnar, less salt-and-pepper whisker map in somatosensory cortex, showing that impoverished experience contributes to intermixed tuning in rodent sensory maps.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Molecular structure of human KATP in complex with ATP and ADP

    Kenneth Pak Kin Lee, Jue Chen, Roderick MacKinnon
    MgADP binding to the high-affinity 'consensus' ATPase active site of SUR1 and remodeling of the L0-loop (lasso region) overrides tonic ATP inhibition of KATP channels.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Development and characterization of new tools for detecting poly(ADP-ribose) in vitro and in vivo

    Sridevi Challa, Keun W Ryu ... W Lee Kraus
    Poly(ADP-ribose) (PAR) Trackers (PAR-Ts) are optimized PAR sensors that allow the detection and quantification of PAR levels in extracts, living cells, and living tissues with high sensitivity, and with temporal and spatial precision, in many different experimental and biological systems.
    1. Developmental Biology

    BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity

    Richard H Row, Amy Pegg ... Benjamin L Martin
    Interplay between FGF-induced bHLH transcription factors and BMP-induced bHLH inhibitory id genes govern mesodermal cell fate choice along the mediolateral axis in both zebrafish and mouse.
    1. Biochemistry and Chemical Biology

    Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2

    Jake W Anderson, David Vaisar ... Natalie G Ahn
    New ATP-competitive inhibitors show properties of conformation selection when complexed with the MAP kinase, ERK2, altering movements around the activation loop.
    1. Cell Biology

    High and stable ATP levels prevent aberrant intracellular protein aggregation in yeast

    Masak Takaine, Hiromi Imamura, Satoshi Yoshida
    The first demonstration that cellular ATP homeostasis suppresses high volatility of cellular ATP levels to ensure proteostasis that prevents accumulation of cytotoxic protein aggregation.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

    Margaret AM Nelson, Kelsey L McLaughlin ... Kelsey H Fisher-Wellman
    Across a physiological span of ATP-free energy, leukemic mitochondria primarily consume, rather than produce, ATP.
    1. Evolutionary Biology

    Preservation of three-dimensional anatomy in phosphatized fossil arthropods enriches evolutionary inference

    Achim H Schwermann, Tomy dos Santos Rolo ... Thomas van de Kamp
    X-ray imaging reveals well-preserved internal characters in mineralized arthropods from the Paleogene, urging the reexamination of previously neglected fossil collections.
    1. Neuroscience

    Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticity

    Amy E Pohodich, Hari Yalamanchili ... Huda Y Zoghbi
    Forniceal deep brain stimulation is a promising treatment for several neuropsychiatric disorders as it upregulates synaptic and neurogenesis-associated genes, normalizes genes misregulated in Rett syndrome mice, and regulates genes altered in intellectual disability and major depression.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of the autoinhibited E. coli ATP synthase in three rotational states

    Meghna Sobti, Callum Smits ... Alastair G Stewart
    A molecular model that provides a framework for interpreting the wealth of functional information obtained on the E. coli F-ATP synthase has been generated using cryo-electron microscopy.

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