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Ecological and evolutionary perspectives are critical to understand, predict, prevent, and treat malaria parasites that may spread to humans from our close primate relatives.

compaRe can be used to optimize cytometric high-parameter immunophenotypic characterization of heterogeneous cell populations.

Chromosomal instability of cancer can be quantitatively measured by phylogenetic analysis of 200 tumor cells while using evolutionary principles to account for cellular selection.

Cryo-electron microscopy reconstructions of two microtubule-bound transport kinesins at 7 Å resolution reveal how microtubule track binding stimulates ADP release, primes the active site for ATP binding and enables force generation.

The first structural and biochemical study of the role of the ATP-cone in anaerobic ribonucleotide reductases shows that dATP allosterically prevents transfer of a glycyl radical to the substrate.

Biochemical analysis on hetero-mutated c₁₀ subunits ring and molecular dynamics simulations demonstrate the cooperation among c-subunits of F_oF₁-ATP synthase in rotation-coupled proton translocation.

More integrated brains in crown birds evolved through a mosaic assembly of new evolutionary and developmental dynamics across neuroanatomical regions that occurred along the dinosaur-bird transition.

Structure-function analyses reveal the mechanistic underpinnings of inside-out transmembrane signaling that controls periplasmic proteolysis, and thereby biofilm formation, in bacteria and may be relevant in the context of other signaling proteins with similar control elements.

AMP-activated protein kinase directly coordinates glutamatergic signalling during starvation in C. elegans.

Histone methylation patterns may differ depending on the enzymatic source of the methyl donor S-adenosylmethionine, suggesting the biological effects of low SAM may affect methylation targets in different ways, depending on the synthase producing it.