301 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    AMPylation matches BiP activity to client protein load in the endoplasmic reticulum

    Steffen Preissler et al.
    Attaching a molecule of adenosine mono-phosphate (AMP) to the BiP protein at threonine 518 regulates its chaperone activity in the endoplasmic reticulum.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    AMPylation targets the rate-limiting step of BiP’s ATPase cycle for its functional inactivation

    Steffen Preissler et al.
    AMPylation of BiP allosterically interferes with stimulation of its ATPase activity by J-proteins that is required for high affinity substrate binding.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a

    Hui Jing et al.
    A new post-translational regulatory mechanism of K-Ras is identified, which expands the function of reversible protein lysine fatty acylation and offers new possibility to target the K-Ras oncoprotein.
    1. Stem Cells and Regenerative Medicine

    Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria

    Carolyn E Adler et al.
    A chemical method has been developed for studying single organ regeneration and fate specification of stem cells in an adult organism.
    1. Biochemistry and Chemical Biology

    Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets

    Kelsie M Rodriguez et al.
    A combined chemical genetics, proximity labeling, and ADP-ribose site mapping approach shows that PARP-7 mono-ADP-ribosylates immune-relevant proteins on cysteine amino acids.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation

    Xiaoyu Zhang et al.
    A posttranslational regulatory mechanism for a Ras family small GTPase could open up new directions to understand and control the Ras family of proteins that are important for physiology and diseases.
    1. Cell Biology
    2. Neuroscience

    Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration

    Andrew T Moehlman et al.
    Tuning of BiP activity by Fic-mediated AMPylation is required for Drosophila photoreceptor plasticity and attenuation of the unfolded protein response.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells

    Lavanya H Palavalli Parsons et al.
    PARP-7 is a mono(ADP-ribosyl) transferase that directs an extensive ADP-ribosylated proteome to control microtubule stability, and regulate ovarian cancer cell growth and motility.
    1. Neuroscience

    Sensory restoration by epidural stimulation of the lateral spinal cord in upper-limb amputees

    Santosh Chandrasekaran et al.
    Cervical spinal cord stimulation evokes sensory percepts in the missing hand and arm of people with upper-limb amputation, regardless of amputation level or time post-amputation.
    1. Biochemistry and Chemical Biology

    Alkylative damage of mRNA leads to ribosome stalling and rescue by trans translation in bacteria

    Erica N Thomas et al.
    Alkylation stress modify mRNAs and results in translation arrest, which activates the ribosome-rescue pathway of trans translation in bacteria.

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