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Page 2 of 155
    1. Cell Biology
    2. Computational and Systems Biology

    Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

    Jakub Tomek et al.
    A computer model of human cardiomyocyte was produced and validated on independent datasets, overcoming shortcomings of its predecessors, also yielding broadly relevant insights and results on major ionic currents.
    1. Biochemistry and Chemical Biology

    Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site

    Fanny Sunden et al.
    Conventional studies have focused on enzymatic residues directly involved in catalysis; dissecting a potential interaction network within which these ‘catalytic residues’ are embedded provides insights fundamental to enzyme function, evolution, and engineering.
    1. Developmental Biology
    2. Physics of Living Systems

    Cell lineage-dependent chiral actomyosin flows drive cellular rearrangements in early Caenorhabditis elegans development

    Lokesh G Pimpale et al.
    Developmentally controlled chiral counter-rotating actomyosin flows drive cell-lineage spindle skews and cell rearrangements during cytokinesis in early nematode development.
    1. Computational and Systems Biology
    2. Neuroscience

    T2N as a new tool for robust electrophysiological modeling demonstrated for mature and adult-born dentate granule cells

    Marcel Beining et al.
    T2N, a novel interface between Matlab, TREES toolbox and NEURON, was used to generate compartmental models that reproduce the electrophysiology of dentate granule cells over a multitude of species, experimental conditions and developmental stages.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict

    James B Eaglesham et al.
    Poxin enzymes are a diverse family of insect and viral 2′3′-cGAMP nucleases, which evolved from self-cleaving RNA virus accessory proteases.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dissecting the DNA binding landscape and gene regulatory network of p63 and p53

    Konstantin Riege et al.
    A resource of p63-regulated genes, genomic loci bound by p63, p63 DNA recognition motifs, and potential co-factors is generated through a meta-analysis of high-throughput datasets.
    1. Cell Biology

    The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition

    Danielle DiTirro et al.
    A Tubby protein regulates ciliary membrane morphology and phosphoinositide composition in a context-dependent manner.
    1. Cell Biology

    Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells

    Jaroslaw Cendrowski et al.
    Erythroid-enriched BMP2K kinase, in addition to its predicted function in endocytosis, regulates distribution and abundance of COPII assemblies and autophagic degradation through opposing actions of its two splicing variants.
    1. Neuroscience

    Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state

    Timothy Bellay et al.
    Spontaneous, irregular spiking in single cortical pyramidal neurons assembles as neuronal avalanches at the group level identifying a robust scale-invariant organization of resting activity in the awake state.
    1. Neuroscience

    The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment

    Shaun S Sanders et al.
    ZDHHC14 controls palmitoylation and axon initial segment targeting of PSD93 and Kv1-family potassium channels, events that are essential for normal neuronal excitability.