2,753 results found
    1. Cell Biology
    2. Immunology and Inflammation

    Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation

    Madison Bolger-Munro et al.
    Arp2/3 complex-mediated actin polymerization shapes how B lymphocytes probe the surface of antigen-presenting cells, promotes coalescence of B cell receptor (BCR) microclusters, amplifies BCR signaling, and enhances B cell activation.
    1. Neuroscience

    APP modulates KCC2 expression and function in hippocampal GABAergic inhibition

    Ming Chen et al.
    APP interacts with KCC2 to limit the latter from tyrosine-phosphorylation and ubiquitination and thus subsequent degradation, revealing a novel molecular pathway in which APP regulates GABAergic signaling and thus inhibition in the hippocampus.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1

    Xiaofei Jia et al.
    HIV-1 viral protein u (Vpu) can stimulate novel versions of canonical interactions with the clathrin adaptor AP1 to counteract the host antiviral protein BST2.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex

    Edward A Partlow et al.
    Cryo-EM reveals how a protein called NECAP inactivates the AP2 clathrin adaptor complex through concerted engagement of two domains which confer specificity for membrane-activated and phosphorylated AP2.
    1. Ecology
    2. Evolutionary Biology

    The African ape-like foot of Ardipithecus ramidus and its implications for the origin of bipedalism

    Thomas Cody Prang
    The most recent common ancestor of humans, chimpanzees, and bonobos possessed a foot adapted to terrestrial quadrupedalism and climbing.
    1. Structural Biology and Molecular Biophysics

    How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4

    Xuefeng Ren et al.
    The structure of the Nef:AP-2 complex has been determined and used as the basis of a model that explains how HIV-1 Nef downregulates the CD4 receptor from the surface of the infected cells.
    1. Cell Biology

    Sumoylation promotes optimal APC/C activation and timely anaphase

    Christine C Lee et al.
    The Anaphase Promoting Complex/Cyclosome is regulated by sumoylation to ensure timely mitotic exit in human cells.
    1. Neuroscience

    Loss of presenilin function is associated with a selective gain of APP function

    Carole Deyts et al.
    Amyloid precursor protein expression and accumulation of its intracellular fragment are required for exuberant neurite outgrowth associated with pathological presenilin 1 loss-of-function mutations before the emergence of amyloid burden in mice.
    1. Cell Biology
    2. Neuroscience

    AP2 hemicomplexes contribute independently to synaptic vesicle endocytosis

    Mingyu Gu et al.
    A protein complex that enables cells to transport substances across their membranes, and that typically consists of four subunits, can also function as two hemicomplexes, each with two subunits.
    1. Cell Biology

    NECAPs are negative regulators of the AP2 clathrin adaptor complex

    Gwendolyn M Beacham et al.
    Endocytosis is regulated by a protein family that recycles the AP2 clathrin adaptor by restoring the inactive form of complex.

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