Transgenic mice with high levels of FGF21 live for longer than wild-type mice and do so without reducing food intake.

Structural and functional studies of a potassium ion channel that is opened and closed by different ligands have revealed a novel gating mechanism.

A combination of molecular dynamics simulations and X-ray diffraction data has been used to construct more realistic models of proteins and to provide new insights into their interactions with other proteins and biomolecules.

Cleavage of a membrane-bound transcription factor by the chemotherapeutic reagent doxorubicin can block the proliferation of tumor cells.

The discovery of a fluorescent protein that can be rapidly switched between long-lived ‘on’ and ‘off’ states will lead to a new generation of super-resolution imaging experiments on living cells.

The nematode worm C. elegans consumes familiar bacterial species more rapidly than it does novel ones, and this preference for familiarity is mediated by a pair of serotonergic neurons.

The Notch signaling pathway has a central role in the development of the nervous system, and also in the establishment of networks of connections in the adult brain

A protein complex that enables cells to transport substances across their membranes, and that typically consists of four subunits, can also function as two hemicomplexes, each with two subunits.

The details of how the enzyme DNA polymerase α initiates the polymerization of nucleotides in DNA replication, a critical step in the synthesis of new chromosomal DNA, have been revealed in atomic detail.

COPII vesicles regulate the metabolism of cholesterol through the selective transport of secretory proteins.