The same membrane trafficking cargo can change pathways mediated by different members of ARF-GEF family of vesicle formation regulators.

New interneurons are added in the hindbrain to support more complex movements as young zebrafish get older.

eLife is publishing a collection of articles and interviews with scientists who are parents to explore how to get the best of both worlds.

Inflammatory bowel disease risk-gene, INAVA and the ARF-GEF ARNO, regulates non-canonical cortical actin assembly and IL-1b signaling to maintain epithelial homeostasis.

A new structure reveals two Arf-GEF regulatory domains form a single structural unit that stimulates Arf-GEF activity.

A small pool of active epidermal growth factor (EGF) receptors, which are capable of ubiquitylation and efficient endocytosis in vivo, is sufficient to support EGF-receptor-dependent tumor growth by signaling primarily through the Ras-MAPK pathway.

Parkin ubiquitination of damaged mitochondria recruits the Rab GEF, RABGEF1, to regulate downstream Rab cycles and ATG9A recruitment to growing phagophores that are participating in mitophagy.