60 results found
    1. Biochemistry and Chemical Biology

    Serine ADP-ribosylation reversal by the hydrolase ARH3

    Pietro Fontana et al.
    ARH3 is an enzyme that hydrolyses serine ADP-ribosylation, a recently uncovered post-translational protein modification.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins

    Katja Gotthardt et al.
    The ciliary G-protein Arl13B – which is often mutated in Joubert syndrome – is the Guanine nucleotide exchange factor for the G-protein Arl3 and exclusively localizes to cilia.
    1. Biochemistry and Chemical Biology

    Post-translational Modifications: Reversing ADP-ribosylation

    Giuliana Katharina Moeller, Gyula Timinszky
    Interactions between serines and molecules of ADP-ribose play an important role in signaling that the DNA in a cell has been damaged and needs to be repaired.
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    1. Biochemistry and Chemical Biology

    Serine is the major residue for ADP-ribosylation upon DNA damage

    Luca Palazzo et al.
    Serine residues in proteins are the primary targets for PARP-dependent ADP-ribosylation signalling upon DNA damage.
    1. Neuroscience

    Reproduction: A kiss to set the rhythm

    Sonal Shruti, Vincent Prevot
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    1. Neuroscience

    Energy imbalance alters Ca2+ handling and excitability of POMC neurons

    Lars Paeger et al.
    The development of diet-dependent obesity results in the deterioration of calcium homeostasis in pro-opiomelanocortin-expressing neurons and impaired function of the same neurons.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

    Meritxell Espino Guarch et al.
    SLC7A8 a neutral amino acid transporter has a key role in the maintenance of hearing during aging and its absence causes early onset of hearing loss.
    1. Evolutionary Biology
    2. Plant Biology

    Origin and evolution of the nuclear auxin response system

    Sumanth K Mutte et al.
    The system that controls gene expression by the plant signaling molecule auxin has deep evolutionary roots, and stepwise increases in system complexity shaped the highly diverse auxin response in land plants.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Nuclear microenvironments modulate transcription from low-affinity enhancers

    Albert Tsai et al.
    Efficient transcription from low-affinity enhancers is driven by nuclear microenvironments of transcription factors.
    1. Plant Biology

    The Arabidopsis thaliana mobilome and its impact at the species level

    Leandro Quadrana et al.
    Population genomics in Arabidopsis thaliana uncovers an extensive repertoire of active transposable element families at the species level and reveals their importance as a source of rare alleles with large effects.

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