18 results found
    1. Cell Biology
    2. Immunology and Inflammation

    Microtubule plus-end dynamics link wound repair to the innate immune response

    Clara Taffoni et al.
    Microtubules orchestrate wound repair and innate immune response in the Caenorhabditis elegans epidermis.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

    Hessel Honkoop et al.
    Single-cell RNA sequencing reveals Nrg1/ErbB2-induced metabolic reprogramming as a pivotal event for cardiomyocyte proliferation during heart regeneration.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation

    Xiaodi Yu et al.
    Cryo-EM structures of unliganded SLC1A5 and its complex with glutamine in outward-facing state provide insights into the substrate specificity and transport mechanism and will be helpful for developing selective inhibitors.
    1. Immunology and Inflammation

    Antigen receptor control of methionine metabolism in T cells

    Linda V Sinclair et al.
    Antigen receptor control of methionine transport is critical to co-ordinate protein synthesis and the production of methyl donors for nucleotide and protein methylations which are required for T cell differentiation.
    1. Cancer Biology

    miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis

    Lihua Wang et al.
    miR-34a prevents inflammation-induced colonic regeneration from oncogenesis by simultaneously targeting processes in both immune and epithelial cells, including T helper 17 cell differentiation, recruitment, and IL-17 induced epithelial proliferation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Consensus designs and thermal stability determinants of a human glutamate transporter

    Erica Cirri et al.
    A fast evolutionary approach to engineer membrane protein kinetic stability yields folded excitatory neurotransmitter transporters and provides insights into their denaturing pathway.
    1. Neuroscience

    Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells

    Justyna Ulanska-Poutanen et al.
    Distinctive microenvironments within demyelinated white matter determine fate decisions of adult oligodendrocyte progenitor cells.
    1. Plant Biology

    DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis

    Amr Nassrallah et al.
    Light signaling components interact with a histone H2B deubiquitination module, adjusting chromatin states at global level during Arabidopsis seedling development.
    1. Cell Biology
    2. Developmental Biology

    Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis

    Preetish Kadur Lakshminarasimha Murthy et al.
    Fringe proteins regulate Notch pathway differentially in the stem cell zone and progenitor compartment of the mouse intestinal epithelium to promote homeostasis.
    1. Immunology and Inflammation

    The transcription factors Runx3 and ThPOK cross-regulate acquisition of cytotoxic function by human Th1 lymphocytes

    Yasmina Serroukh et al.
    The acquisition of cytotoxic function by human CD4 T cells is an integral part of the T helper 1 differentiation pathway and is limited by the transcription factor ThPOK.

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