9,856 results found
    1. Neuroscience

    Dopaminergic neurons write and update memories with cell-type-specific rules

    Yoshinori Aso, Gerald M Rubin
    Building on previous work (Aso et al., 2014a; Aso et al., 2014b), cell-type-specific drivers and optogenetics are used to control the local release of dopamine and reveal that distinct learning rules are implemented in parallel memory units.
    1. Neuroscience

    Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila

    Yoshinori Aso et al.
    Output neurons in the mushroom body of the fruit fly brain encode the positive or negative survival value of stimuli, enabling insects to choose adaptive approach and avoidance behaviors through associative learning.
    1. Neuroscience

    Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics

    Yoshinori Aso et al.
    The interplay of nitric oxide and dopamine specialize one memory unit in a fly brain in predicting the value of odors based only on recent experience.
    1. Developmental Biology

    Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development

    David AD Munro et al.
    Embryonic macrophages encourage early kidney development, interact with developing renal blood vessels, are enriched for mRNAs linked to vascular development, and promote endothelial cross-connections.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53

    Syafiq Abd Wahab, Dirk Remus
    The mechanism of Dbf4-dependent kinase (DDK) recruitment to replication origins and its regulation by the checkpoint have been identified.
  1. Scientific Publishing: Recognizing the importance of new tools and resources for research

    Randy Schekman et al.
    eLife is introducing a new article type—called Tools and Resources—to highlight new experimental techniques, datasets, software tools and other resources.
    Editorial
    Available as:
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    • PDF
  2. Point of View: Science, art, society and Klimt’s University of Vienna paintings

    Alberto E Pereda
    A set of paintings by Gustav Klimt highlights ongoing tensions in the relationships between art, science and society.
  3. Point of View: When it comes to teaching and tenure it is time to walk the walk

    Andrew W Murray et al.
    Institutions should value teaching and service, and not just research, when considering faculty for promotion and tenure.
  4. Research Communication: Ways to increase equity, diversity and inclusion

    Devang Mehta et al.
    ​​ The eLife Early-Career Advisory Group calls for radical changes at eLife and other journals to make science more diverse and inclusive.
    Editorial
    Available as:
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    1. Neuroscience

    CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory

    Miou Zhou et al.
    Repression of the G protein-coupled chemokine receptor CCR5 enhances MAPK/CREB signaling, long-term potentiation, somatosensory cortical plasticity, and learning and memory, while CCR5 over-activation by viral proteins may contribute to HIV-associated cognitive deficits.

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