75 results found
    1. Biochemistry and Chemical Biology

    Translation of 5′ leaders is pervasive in genes resistant to eIF2 repression

    Dmitry E Andreev et al.
    Most of the mRNAs whose translation is resistant to the stress-induced repression of protein synthesis contain upstream open reading frames that are efficiently translated under normal conditions.
    1. Cell Biology

    Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress

    Ciara M Gallagher, Peter Walter
    Ceapins specifically inhibit ATF6α signaling by preventing its transport to the Golgi during endoplasmic reticulum stress.
    1. Cell Biology

    Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

    Ciara M Gallagher et al.
    Ceapins enable selective pharmacological inhibition of the cytoprotective transcriptional response to endoplasmic reticulum stress through ATF6α without affecting other branches of the unfolded protein response.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments

    Svetlana O Dodonova et al.
    A molecular model of the assembled COPI coat, determined by cryo-electron tomography of an in vitro reconstituted budding reaction, reveals details of interactions mediating coat assembly and shows the binding site of ArfGAP2.
    1. Neuroscience

    Selective rab11 transport and the intrinsic regenerative ability of CNS axons

    Hiroaki Koseki et al.
    Mature axons lose the ability to regenerate because key growth molecules are excluded through changes in vesicle transport, and restoring transport can restore regeneration.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response

    Xing-Huang Gao et al.
    ATF4, the master regulator of transcription during the Integrated Stress Response (ISR), causes global changes in cysteine sulfhydration of proteins and this event causes cellular metabolic reprogramming.
    1. Cancer Biology
    2. Cell Biology

    Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells

    Michiel van Veen et al.
    GDE3 is a transmembrane GPI-specific phospholipase C that sheds the urokinase receptor (uPAR) from the cell surface resulting in loss of uPAR function in breast cancer cells and reduced tumor growth.
    1. Cancer Biology

    Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma

    Nataša Pavlović et al.
    Inhibiting IRE1α decreases tumor cell proliferation and migration in hepatocellular carcinoma, therefore components of this ER-stress pathway may be therapeutically relevant for liver cancer.
    1. Cell Biology

    Unfolded Protein Response: Modulating protein quality control

    Lars Plate et al.
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    1. Cell Biology
    2. Neuroscience

    Cell Biology: Less translational control, more memory

    Graham D Pavitt
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