13,421 results found
    1. Cancer Biology

    Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation

    Sophia M Blake, Stefan H Stricker ... Axel Behrens
    Deletion of the ATM cofactor ATMIN reduces PDGFRA expression and strongly suppresses tumorigenesis in a TP53-deficient mouse model of glioblastoma.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

    Minxian Qian, Zuojun Liu ... Baohua Liu
    The ATM-SIRT6 axis integrates the DNA repair machinery to longevity-promoting pathways.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion

    Wei-Ta Chen, Nancy D Ebelt ... Kyle M Miller
    The ATM kinase has an unanticipated role in tumor progression through the regulation of cell migration by oxidative stress.
    1. Ecology

    Sequestration and activation of plant toxins protect the western corn rootworm from enemies at multiple trophic levels

    Christelle AM Robert, Xi Zhang ... Jonathan Gershenzon
    The western corn rootworm escapes biological control by entomopathogenic nematodes by partitioning and phenocopying the plant defense system for self-protection.
    1. Neuroscience

    Functional connectivity subtypes associate robustly with ASD diagnosis

    Sebastian GW Urchs, Angela Tam ... Pierre Bellec
    Unsupervised clustering of the heterogeneous functional brain organization in autism reveals generalizable patterns of connectivity alterations that extend to the general population.
    1. Physics of Living Systems

    The younger flagellum sets the beat for Chlamydomonas reinhardtii

    Da Wei, Greta Quaranta ... Daniel SW Tam
    External hydrodynamic forcing on each flagellum of Chlamydomonas reinhardtii reveals a leader-follower relation between the two flagella in the synchronous beating.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Phosphoproteomics of ATR signaling in mouse testes

    Jennie R Sims, Vitor M Faça ... Marcus B Smolka
    An in-depth map of ATR signaling during mouse meiosis is revealed using a combination of genetic and pharmacological approaches coupled to quantitative mass spectrometry.
    1. Chromosomes and Gene Expression

    Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations

    Jiying Sun, Lin Shi ... Satoshi Tashiro
    ATM plays an important role in maintaining the fidelity of DNA repair through the regulation of ARP8 phosphorylation to prevent the chromosome abnormality.
    1. Computational and Systems Biology

    DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

    Vivian Tam, Peikai Chen ... Danny Chan
    Deep and comprehensive proteomic resource of human intervertebral disc at high spatial resolution with a methodological flow reveals new insights in disc homeostasis and degeneration.
    1. Cell Biology
    2. Developmental Biology

    An in vitro stem cell model of human epiblast and yolk sac interaction

    Kirsty ML Mackinlay, Bailey AT Weatherbee ... Magdalena Zernicka-Goetz
    Human yolk sac-like cells, which share characteristics with the post-implantation human hypoblast, can model the interaction between the epiblast and hypoblast that occurs during early human development.

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