5,622 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Low-dimensional learned feature spaces quantify individual and group differences in vocal repertoires

    Jack Goffinet et al.
    Modern machine learning methods offer new techniques for analyzing complex vocal behavior like ultrasonic mouse calls and birdsong.
    1. Biochemistry and Chemical Biology

    The molecular coupling between substrate recognition and ATP turnover in a AAA+ hexameric helicase loader

    Neha Puri et al.
    Structure-guided biochemistry defines how the coupling between nucleic acid substrate binding and ATPase activity is used by a molecular switch to load ring-shaped motor proteins onto single-stranded DNA.
    1. Immunology and Inflammation

    Protective function and durability of mouse lymph node-resident memory CD8+ T cells

    Scott M Anthony et al.
    Repeated antigen encounters alter the transcriptional state and function of lymph node-resident memory CD8+ T cells to mediate improved immunity against viral infection.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Regional sequencing collaboration reveals persistence of the T12 Vibrio cholerae O1 lineage in West Africa

    Eme Ekeng et al.
    The T12 Vibrio cholerae lineage has been continuously circulating in West Africa since at least 2012, highlighting the importance of regional disease control efforts.
    1. Cell Biology
    2. Neuroscience

    High-fidelity, efficient, and reversible labeling of endogenous proteins using CRISPR-based designer exon insertion

    Haining Zhong et al.
    A high-fidelity and efficient strategy to use CRISPR/Cas9 to reversibly insert large DNA fragments into somatic cells to label or modify endogenous proteins for research and, in the future, for gene therapy.
    1. Biochemistry and Chemical Biology

    Membrane Fusion: Molecular machinery turns full circle

    Josep Rizo et al.
    Two proteins called Sec17 and Sec18 may have a larger role in membrane fusion than is commonly assumed in textbook models.
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    1. Developmental Biology
    2. Neuroscience

    Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway

    Shu-Min Chou et al.
    Kv1.1 potassium channels regulate postnatal neurogenesis in the hippocampus via increasing the membrane excitability that activates the TrkB signaling pathway in a cell-autonomous manner.
    1. Ecology

    The effect of host community functional traits on plant disease risk varies along an elevational gradient

    Fletcher W Halliday et al.
    Environmental gradients can modify a fundamental relationship between host community structure and disease, with implications for predicting disease risk in a changing world.
    1. Developmental Biology
    2. Evolutionary Biology

    Early maternal loss leads to short- but not long-term effects on diurnal cortisol slopes in wild chimpanzees

    Cédric Girard-Buttoz et al.
    Wild chimpanzees contrast to humans since adult male chimpanzees do not exhibit physiological indicators of biological embedding of the stress associated to maternal loss early in life.

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