4,484 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

    Tingting Wang et al.
    The transcription factor (TF)-binding specificities of Pseudomonas aeruginosa allow us to predict virulence-associated TFs and their target genes, which will facilitate to find effective treatment and prevention for its associated diseases.
    1. Neuroscience

    Signed and unsigned reward prediction errors dynamically enhance learning and memory

    Nina Rouhani, Yael Niv
    Throughout learning, both unexpected outcomes and the predictive value of cues modulate learning rate and episodic memory, thereby supporting two seemingly opposing theories of associative learning.
    1. Developmental Biology

    In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration

    Mira I Pronobis et al.
    Proximity labeling-based proteomic strategies applied in zebrafish identify new insights into protein network changes in heart muscle cells during regeneration and implicate Rho A as a target of ErbB2 signaling during zebrafish heart regeneration.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Complementary biosensors reveal different G-protein signaling modes triggered by GPCRs and non-receptor activators

    Mikel Garcia-Marcos
    Heterotrimeric G-proteins can be switched on not only by G-protein-coupled receptors but also by cytoplasmic proteins, resulting in different signaling mechanisms in cells depending on the specific type of activator.
    1. Immunology and Inflammation
    2. Medicine

    An open label trial of anakinra to prevent respiratory failure in COVID-19

    Evdoxia Kyriazopoulou et al.
    Early suPAR-guided anakinra decreases the risk for severe respiratory failure in SARS-CoV-2 pneumonia and restores the pro-/anti-inflammatory balance.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq

    Elliott Swanson et al.
    Simultaneous multimodal measurement of chromatin accessibility, gene expression, and protein expression provides a unified view of the molecular underpinnings of immune cell state in health and disease.
    1. Cell Biology

    Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein

    Nicole R Gould et al.
    Mechanical loading and the bone anabolic action of parathyroid hormone result in rapid, lysosomal degradation of sclerostin protein, revealing physiologically important post-translational control of this critical regulator of bone formation.
    1. Ecology

    Global gradients in intertidal species richness and functional groups

    Jakob Thyrring, Lloyd S Peck
    No discernible latitudinal diversity gradient in rocky intertidal α-diversity as local-scale physical and biological processes outweigh global-scale environmental gradients.
    1. Neuroscience

    Properties of multivesicular release from mouse rod photoreceptors support transmission of single-photon responses

    Cassandra L Hays et al.
    To improve the reliability of transmitting small single-photon voltage responses, rod photoreceptor cells release synaptic vesicles in regularly timed multivesicular events that are exquisitely sensitive to small voltage changes.
    1. Computational and Systems Biology
    2. Neuroscience

    Graphical-model framework for automated annotation of cell identities in dense cellular images

    Shivesh Chaudhary et al.
    Unbiased and automatic annotation using structured prediction framework with efficiently built data-driven atlases is more accurate than registration-based methods for cell identifications in dense images and enables fast whole-brain analysis.

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