4,484 results found
    1. Cell Biology
    2. Physics of Living Systems

    Mechanically stimulated ATP release from murine bone cells is regulated by a balance of injury and repair

    Nicholas Mikolajewicz et al.
    Bone cells exposed to physiological forces release ATP through repairable membrane injury, generating an intercellular signal that conveys the destructive potential of forces and the adaptive capacity of endangered cells.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Connexin-43-dependent ATP release mediates macrophage activation during sepsis

    Michel Dosch et al.
    Autocrine activation of macrophages is modulated by Connexin-43-mediated ATP release in response to TLR-4 and -2 agonists in a P2Y1-dependent manner, ultimately determining sepsis survival.
    1. Structural Biology and Molecular Biophysics

    Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

    Joseph Atherton et al.
    Cryo-electron microscopy reconstructions of two microtubule-bound transport kinesins at 7 Å resolution reveal how microtubule track binding stimulates ADP release, primes the active site for ATP binding and enables force generation.
    1. Neuroscience

    Nanodomain coupling explains Ca2+ independence of transmitter release time course at a fast central synapse

    Itaru Arai, Peter Jonas
    Ca2+ channels and release sensors at a fast central synapse are tightly coupled, which minimizes the effect of extracellular Ca2+ concentration on the timing of transmitter release.
    1. Neuroscience

    APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses

    Tomas Fanutza et al.
    A naturally occurring intracellular peptide, derived by processing the Alzheimer's protein APP, reduces synaptic transmission by acting as a dominant negative of APP.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Ca2+-dependent release of synaptotagmin-1 from the SNARE complex on phosphatidylinositol 4,5-bisphosphate-containing membranes

    Rashmi Voleti et al.
    Ca2+-free synaptotagmin-1 binds to neuronal SNARE complexes anchored on nanodiscs, and Ca2+ releases this interaction to induce tight, specific binding to PIP2-containing membranes.
    1. Neuroscience

    RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses

    Marisa M Brockmann et al.
    The active zone scaffold protein RIM-BP2 performs distinct functions in vesicle release at two hippocampal synapses, providing insights on how synapses express diversity in release properties.
    1. Neuroscience

    Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP

    Junhua Yang et al.
    Astrocytes regulate the pruning of excitatory synapses during early life through ATP signaling.
    1. Neuroscience

    Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling

    Francie Moehring et al.
    Keratinocytes are critical for normal innocuous and noxious touch through their mechanically evoked ATP release and subsequent signaling to P2X4 channels on sensory neurons.
    1. Neuroscience

    Glutamate is required for depression but not potentiation of long-term presynaptic function

    Zahid Padamsey et al.
    Electrophysiological and optical analysis of neurotransmitter release at central synapses reveals that glutamate signalling is not required for the long-term potentiation (LTP) of presynaptic function, and instead only promotes presynaptic long-term depression (LTD).

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