4,409 results found
    1. Cell Biology
    2. Plant Biology

    Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in translation

    M Regina Scarpin et al.
    Plants and humans use a shared mechanism, the eukaryotic metabolic sensor TARGET OF RAPAMYCIN protein kinase and its substrate, an RNA-binding protein called LARP1, to coordinate post-transcriptional gene expression.
    1. Cancer Biology
    2. Immunology and Inflammation

    Cytotoxic T-cells mediate exercise-induced reductions in tumor growth

    Helene Rundqvist et al.
    Exercise can induce metabolic changes that strikingly impact cytotoxic T cell function and in turn affect cancer progression.
    1. Structural Biology and Molecular Biophysics

    Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation

    Georg Kuenze et al.
    An integrative structural biology approach provides refined models of the KCNQ1-KCNE1 channel complex, which propose a new mechanism to explain how KCNE1 modulates KCNQ1 channel activation.
    1. Neuroscience

    Direct translation of climbing fiber burst-mediated sensory coding into post-synaptic Purkinje cell dendritic calcium

    Seung-Eon Roh et al.
    Purkinje cell dendritic calcium response is finely controlled by the burst activity of climbing fiber during sensory coding.
    1. Genetics and Genomics
    2. Neuroscience

    Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice

    Marina Kovalenko et al.
    Genetic knockout of Hdac2 modifies molecular and cellular phenotypes in Huntington’s disease mice and has a prominent transcriptional regulatory role in adult medium spiny neurons.
    1. Biochemistry and Chemical Biology

    A novel DNA primase-helicase pair encoded by SCCmec elements

    Aleksandra Bebel et al.
    SCCmec genomic islands encode a novel primase-helicase pair in which priming ability is conferred upon an A-family DNA polymerase domain by a novel protein cofactor.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity

    Mark Shaaya et al.
    Light-sensitive allosteric switch module, a broadly applicable protein engineering method, is used for the regulation of protein activity with tight temporal control and spatial precision.
    1. Computational and Systems Biology

    A large accessory protein interactome is rewired across environments

    Zhimin Liu et al.
    A massively multiplexed multi-condition screen shows that protein interactomes are larger than previously thought and contain highly dynamic regions that reorganize to drive or respond to cellular changes.
    1. Neuroscience

    Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain

    Lynne Chantranupong et al.
    Extensive mass spectrometry-based profiling of polar metabolites within synaptic vesicles that are rapidly isolated either from cultured mouse neurons or directly from mouse brains reveals their neurotransmitter composition.

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