5,350 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion

    Wei-Ta Chen et al.
    The ATM kinase has an unanticipated role in tumor progression through the regulation of cell migration by oxidative stress.
    1. Cell Biology
    2. Immunology and Inflammation

    ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA

    Charlotte Lässig et al.
    Mutations within the ATPase domain of RIG-I in patients with Singleton-Merten Syndrome prevent ATP-hydrolysis dependent dissociation of RIG-I from double-stranded RNA and lead to unintentional constitutive signaling through increased binding of endogenous RNA.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin

    Ben C Tilly et al.
    Visualization of BRM remodelers engaging their endogenous genomic targets revealed highly transient and dynamic interactions with chromatin, which are fueled by ATP-hydrolysis.
    1. Chromosomes and Gene Expression

    Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription

    Vincenzo Di Cerbo et al.
    The acetylation of histones at specific sites close to DNA can regulate transcription.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Molecular structure of human KATP in complex with ATP and ADP

    Kenneth Pak Kin Lee et al.
    MgADP binding to the high-affinity 'consensus' ATPase active site of SUR1 and remodeling of the L0-loop (lasso region) overrides tonic ATP inhibition of KATP channels.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress

    Joseph M Cabral et al.
    Epigenetic restriction of herpes simplex virus occurs in a biphasic manner, in which ATRX maintains viral heterochromatin after an initial phase of chromatin deposition.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of the autoinhibited E. coli ATP synthase in three rotational states

    Meghna Sobti et al.
    A molecular model that provides a framework for interpreting the wealth of functional information obtained on the E. coli F-ATP synthase has been generated using cryo-electron microscopy.
    1. Cancer Biology

    Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation

    Sophia M Blake et al.
    Deletion of the ATM cofactor ATMIN reduces PDGFRA expression and strongly suppresses tumorigenesis in a TP53-deficient mouse model of glioblastoma.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

    Minxian Qian et al.
    The ATM-SIRT6 axis integrates the DNA repair machinery to longevity-promoting pathways.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM

    Anna Zhou et al.
    Structural analysis of the ATP synthase – in combination with evolutionary covariance analysis – reveals the fold of the a subunit and shows that the enzyme can adopt several different conformations, which support the Brownian ratchet model for generating rotation.

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