Epigenetic restriction of herpes simplex virus occurs in a biphasic manner, in which ATRX maintains viral heterochromatin after an initial phase of chromatin deposition.
An in-depth map of ATR signaling during mouse meiosis is revealed using a combination of genetic and pharmacological approaches coupled to quantitative mass spectrometry.
ATM plays an important role in maintaining the fidelity of DNA repair through the regulation of ARP8 phosphorylation to prevent the chromosome abnormality.
Catalina Pereira, Gerardo A Arroyo-Martinez ... Robert S Weiss
Alternative 9-1-1 complexes have evolved to play essential roles in mammalian meiosis and function to activate the protein kinase ATR and promote key meiotic events necessary for fertility.
Sina Atashpaz, Sara Samadi Shams ... Vincenzo Costanzo
ATR protects stem cell genomes by activating a transcriptional response mediated by totipotency genes, conferring trophoblast differentiation potential, the derepression of which in somatic cells might favour cancer features emergence.
Sana Ahmed-Seghir, Manisha Jalan ... Simon N Powell
Cells exhibit a localized ATR-dependent DNA damage response to a site-specific stalled replication fork that is distinct from that observed after global replication stress.
Carolline Ascenção, Jennie R Sims ... Marcus B Smolka
A Topbp1 mutant mouse reveals a non-canonical role for the ATR-TOPBP1 signaling axis in meiosis, separating ATR signaling and meiotic sex chromosome inactivation from sex body formation.
Distinct interactions of AP endonuclease 1 with single-stranded DNA gaps and ATRIP and RPA protein complex address an outstanding question in the field of genome integrity regarding how ATR/ATRIP complex recruits onto damage site for ATR DNA damage response signaling.
Reactive oxygen species can activate the ATR/Chk1 pathway in the absence of detectable DNA damage and without a requirement for DNA damage response proteins.
