170 results found
    1. Structural Biology and Molecular Biophysics

    Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity

    Zhijie Lin et al.
    A systematic and quantitative investigation showing how highly specific WW domain-mediated protein-protein interaction network is organized in cell growth and polarity.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Formin-2 drives polymerisation of actin filaments enabling segregation of apicoplasts and cytokinesis in Plasmodium falciparum

    Johannes Felix Stortz et al.
    Formin-2 controls spatiotemporal polymerisation of actin filaments, a common mechanism used by apicomplexans for effective segregation of essential chloroplast-like organelles called apicoplasts, and additionally for daughter formation in Plasmodium falciparum.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A requirement of Polo-like kinase 1 in murine embryonic myogenesis and adult muscle regeneration

    Zhihao Jia et al.
    Inhibition of Polo-like kinase that has been shown to exhibit antitumor effect unexpectedly disrupts muscle stem cell function, leading to developmental and regenerative failures.
    1. Chromosomes and Gene Expression

    piRNA-guided co-transcriptional silencing coopts nuclear export factors

    Martin H Fabry et al.
    A member of the Drosophila Nuclear Export Factor (Nxf) family, Nxf2, forms part of the piRNA-dependent co-transcriptional silencing complex and is essential for transposon repression in fly ovaries.
    1. Developmental Biology

    In vivo study of gene expression with an enhanced dual-color fluorescent transcriptional timer

    Li He et al.
    A simple and effective method facilitates the study of in vivo transcriptional dynamics using transcriptional enhancers and destabilized fluorescent protein, which is suitable for both live imaging and fixed studies.
    1. Developmental Biology
    2. Neuroscience

    Anterior CNS expansion driven by brain transcription factors

    Jesús Rodriguez Curt et al.
    The expansion of the anterior Drosophila CNS is driven by increased progenitor generation and prolonged proliferation, mediated by brain-restricted genes and the PRC2.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

    Min Jung et al.
    A statistical method for summarizing single-cell gene expression data identifies normal and disease-specific transcriptional programs from an atlas of 57,600 cells.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Genetic interactions of G-quadruplexes in humans

    Katherine G Zyner et al.
    For the first time, the spectrum of genes and pathways interacting with alternative DNA structures called G-quadruplexes in humans is revealed highlighting new possibilities for the pursuit of cancer therapies.
    1. Neuroscience

    The manifold structure of limb coordination in walking Drosophila

    Brian D DeAngelis et al.
    During walking and turning, the fruit fly Drosophila uses variable limb coordination patterns, which exist on a low-dimensional, continuous manifold.
    1. Neuroscience

    optoPAD, a closed-loop optogenetics system to study the circuit basis of feeding behaviors

    José-Maria Moreira et al.
    The optoPAD system combines real-time behavioral analysis with optogenetic manipulations to study how animals adapt to dynamic gustatory environments and to identify the circuit basis of feeding.

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