148 results found
    1. Computational and Systems Biology
    2. Medicine

    Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations

    Xin Zhou, Zhinuo Jenny Wang ... Blanca Rodriguez
    Human-based electromechanical simulations reveal electrocardiogram biomarkers are better indicators of pro-arrhythmic substrate after myocardial infarction than ejection fraction.
    1. Cell Biology
    2. Evolutionary Biology

    Sterol transfer by atypical cholesterol-binding NPC2 proteins in coral-algal symbiosis

    Elizabeth Ann Hambleton, Victor Arnold Shivas Jones ... Annika Guse
    Diversification of a conserved cholesterol binder drives functional replacement of cholesterol with symbiont-produced sterols in corals living in nutrient-poor environments.
    1. Neuroscience

    The unique synaptic circuitry of specialized olfactory glomeruli in Drosophila melanogaster

    Lydia Gruber, Rafael Cantera ... Jürgen Rybak
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Evolutionary Biology

    The paradox of extremely fast evolution driven by genetic drift in multi-copy gene systems

    Xiaopei Wang, Yongsen Ruan ... Haijun Wen
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Neuroscience

    A neural correlate of individual odor preference in Drosophila

    Matthew A Churgin, Danylo O Lavrentovich ... Benjamin de Bivort
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Enhancing and inhibitory motifs regulate CD4 activity

    Mark S Lee, Peter J Tuohy ... Michael S Kuhns
    Eutherian CD4 evolved counterbalancing motifs in the extracellular, transmembrane, and intracellular domains that regulate CD4+ T cell responses to peptide antigens presented by class II MHC (pMHCII).
    1. Cancer Biology

    Timing of treatment shapes the path to androgen receptor signaling inhibitor resistance in prostate cancer

    Eugine Lee, Zeda Zhang ... Charles L. Sawyers
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Immunology and Inflammation

    T cell immunodominance is dictated by the positively selecting self-peptide

    Wan-Lin Lo, Benjamin D Solomon ... Paul M Allen
    The T cell repertoire can display immunodominance to an epitope as a result of optimal positive selection in the thymus by one self-peptide/MHC ligand.
    1. Evolutionary Biology

    Species-specific chromatin landscape determines how transposable elements shape genome evolution

    Yuheng Huang, Harsh Shukla, Yuh Chwen G Lee
    The ultimate driver for the substantial between-species difference in the success of transposable elements, the widely distributed genetic parasite, may lie in the overall chromatin environment.
    1. Neuroscience

    Neural pattern change during encoding of a narrative predicts retrospective duration estimates

    Olga Lositsky, Janice Chen ... Kenneth A Norman
    Judgments of how much time elapsed between two events in a story are predicted by changes in fMRI activity patterns.

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