244 results found
    1. Genetics and Genomics

    Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture

    Haiko Schurz, Vivek Naranbhai ... International Tuberculosis Host Genetics Consortium
    Results from the largest tuberculosis genome-wide association study meta-analysis identified a significant association in the human leukocyte antigen class II region, rs28383206, across multiple populations.
    1. Neuroscience

    Transforming descending input into behavior: The organization of premotor circuits in the Drosophila Male Adult Nerve Cord connectome

    Han SJ Cheong, Katharina Eichler ... Gwyneth M Card
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Evolutionary Biology

    A Bayesian approach to dynamic homology of morphological characters and the ancestral phenotype of jawed vertebrates

    Benedict King, Martin Rücklin
    The ancestor of all known jawed vertebrates possessed a maxilla and premaxilla and was similar in morphology to the 'maxillate placoderms' from China.
    1. Cell Biology

    Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised

    Sara Sannino, Megan E Yates ... Jeffrey L Brodsky
    Unique integrate stress response sensors differentially trigger pro-survival versus pro-apoptotic responses in cells confronted with Hsp70 inhibitor-associated proteotoxic challenges.
    1. Cell Biology
    2. Neuroscience

    Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins

    Belgin Yalçın, Lu Zhao ... Cahir J O'Kane
    Proteins of the reticulon and REEP families, homologous to the products of human Hereditary Spastic Paraplegia disease genes, contribute to shaping and continuity of the axonal endoplasmic reticulum network in Drosophila.
    1. Microbiology and Infectious Disease

    Human immunodeficiency virus-1 induces host genomic R-loops and preferentially integrates its genome near the R-loop regions

    Kiwon Park, Dohoon Lee ... Kwangseog Ahn
    Investigation of the role of triple-stranded nucleic acid, R-loops, in HIV-1 genome integration.
    1. Neuroscience

    A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

    Brad K Hulse, Hannah Haberkern ... Vivek Jayaraman
    An analysis of the first complete synaptic resolution connectome of Drosophila's navigation circuit uncovers neural network motifs supporting broadly relevant sensorimotor computations.
    1. Evolutionary Biology

    A non-archaeopterygid avialan theropod from the Late Jurassic of southern Germany

    Oliver WM Rauhut, Helmut Tischlinger, Christian Foth
    A new taxon from the Late Jurassic of southern Germany represents the second volant bird known from that time period and documents the improvement of flapping flight in bird evolution.
    1. Structural Biology and Molecular Biophysics

    A complex IRES at the 5'-UTR of a viral mRNA assembles a functional 48S complex via an uAUG intermediate

    Ritam Neupane, Vera P Pisareva ... Israel S Fernández
    The ribosome bound structure of a new IRES reveals novel architecture features used by viruses to hijack cellular translation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Endoparasitoid lifestyle promotes endogenization and domestication of dsDNA viruses

    Benjamin Guinet, David Lepetit ... Julien Varaldi
    The propensity to endogenize and domesticate dsDNA viruses depends on lifestyle in Hymenoptera.

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