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Mathematical modeling shows how RAF inhibitors can actually activate RAF kinases by stabilizing RAF proteins in the conformation capable of dimerization.

An antagonism between Spinophilin and Syd-1 converge on presynaptic actin to control presynaptic plasticity and memory consolidation in the Drosophila mushroom body.

The vasopressin type 2 receptor promotes dual Gα_s and Gα_q/11 signaling at early endosomes in β-arrestin-dependent and -independent manners.

Voltage-gated calcium channel delivery to synaptic active zones (AZs) occurs broadly across the population, correlates with AZ size, and is regulated by α2δ, while channel recycling is promoted by new delivery to generate an upper limit on AZ accumulation.

In the absence of centrioles, components of pericentriolar material can self-organize into a single compact microtubule-organizing center through dynein-mediated transport of pericentrin-containing protein complexes if CAMSAP- and Golgi-mediated pathways of microtubule minus-end stabilization and anchoring are disabled.

The G protein-coupled receptors FFA2 and FFA3, activated by short-chain fatty acids, are mediators of a gut–brain axis.

The regulatory subunit of protein kinase A (PKA) can both activate and suppress the PKA activity at the plasma membrane, with its graded membrane localization capable of inducing a switch in cell migration.

Quantitative super-resolution correlative light and electron microscopy reveals a constant glycine receptor density at native spinal cord synapses that is maintained in the oscillator mouse model of human hyperekplexia.

Loss of the decoy SNARE Tomosyn enhances synaptic vesicle docking and neurotransmitter release and regulates release and plasticity differences between tonic and phasic motoneurons in Drosophila.

Endothelial pannexin 1-P2Y2 purinergic receptor-TRPV4 channel signaling, facilitated by caveolin-1, is a novel pathway for lowering pulmonary arterial pressure.