1,528 results found
    1. Cancer Biology

    Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

    CheukMan C Au et al.
    3D culture of breast cancer in biologically relevant ECM potentiates the growth-inhibitory effects of unacylated ghrelin and AZP-531, and clinical response may be predictable based on a MAPK gene signature.
    1. Cell Biology

    Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

    Huiliang Zhang et al.
    The primary respiratory defect seen in aged cardiomyocytes is an elevated proton leak mediated by ANT1, and this is prevented by treatment with SS-31 (elamipretide).
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Diverse viral proteases activate the NLRP1 inflammasome

    Brian V Tsu et al.
    Proteases from diverse viruses, the first described pathogen-encoded activators of human NLRP1, cleave NLRP1 at a sequence that mimics the viral polyprotein, resulting in inflammasome activation and pro-inflammatory cytokine release.
    1. Neuroscience

    Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus

    Francois M Lambert et al.
    Molecular labeling, electrophysiology and calcium imaging have revealed a novel switching of neurotransmitter at the frog neuromuscular junction where motoneurons transiently release glutamate before acetylcholine at synapses on developing hindlimb muscles at the onset of metamorphosis.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA

    Flora S Groothuizen et al.
    Visualization of the sliding clamp in DNA mismatch repair shows how a transient complex is activated.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia

    F Esra Demircioglu et al.
    High resolution structures of the essential human AAA+ ATPase TorsinA and its disease mutant in complex with an activator reveal details of the interaction that will guide drug design and further functional characterization.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Profiling the Escherichia coli membrane protein interactome captured in Peptidisc libraries

    Michael Luke Carlson et al.
    Trapping of the cell envelope proteome into water-soluble peptidisc library allows high-throughput definition of the membrane protein interactome.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Residue-by-residue analysis of cotranslational membrane protein integration in vivo

    Felix Nicolaus et al.
    The cotranslational membrane integration of three multispanning Escherichia coli inner membrane proteins is followed using force profile analysis, uncovering unexpected complexities in the membrane integration process.
    1. Structural Biology and Molecular Biophysics

    Exploring conformational equilibria of a heterodimeric ABC transporter

    M Hadi Timachi et al.
    A heterodimeric exporter exhibits conformational equilibria in the presence of nucleotides, suggesting a unified mechanistic model for the conformational cycle of ABC exporters.
    1. Structural Biology and Molecular Biophysics

    The structure of SV40 large T hexameric helicase in complex with AT-rich origin DNA

    Dahai Gai et al.
    A structural study reveals how the simian virus 40 Large-T hexamer helicase interacts with its origin DNA and partially melts the origin double-stranded DNA within the hexamer channel.

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