14 results found
    1. Cell Biology

    Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade

    Laurence Abrami et al.
    Cycles of palmitoylation-depalmitoylation by an upstream palmitoyltransferase allow precise tuning of DHHC6 activity, which in turn regulates the abundance and function of key ER proteins involved in protein folding, degradation, ER architecture and calcium homeostasis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization

    David Tse Shen Lin, Elizabeth Conibear
    Palmitate turnover is controlled by distinct enzyme families with different specificities.
    1. Cancer Biology
    2. Cell Biology

    Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior

    Rochelle Shirin Sadeghi et al.
    Phosphorylation of serine residues 209 and 210 on APT1 increases its depalmitoylating activity, promoting Wnt5a mediated melanoma cell invasion.
    1. Genetics and Genomics

    Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster

    Lauren M Dembeck et al.
    Genome wide association analyses in a wild-derived Drosophila melanogaster population uncover extensive variation in cuticular hydrocarbon composition, which may present a target for natural selection and adaptive evolution.
    1. Biochemistry and Chemical Biology

    Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

    Masatoshi Miyamoto et al.
    (O-Acyl)-ω-hydroxy fatty acids and their derivatives, produced by the fatty acid ω-hydroxylase Cyp4f39, form a lipid polarity gradient in the lipid layer of the tear film and prevent dry eye.
    1. Cancer Biology
    2. Cell Biology

    Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis

    Peng Liao et al.
    Palmitoylation recruits the phosphatase SCP1 to endothelial cell membranes where it negatively regulates Akt kinase activity, resulting in suppressed angiogenesis and decreased tumorigenesis.
    1. Genetics and Genomics

    Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

    Angela Schulz et al.
    Genetic and functional studies reveal a previously unrecognized role for a transmembrane protein in glomerular filtration barrier function.
    1. Neuroscience

    Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model

    Kevin P Koster et al.
    NMDA receptor function is regulated by protein depalmitoylation during visual cortical maturation and is dysfunctional in infantile neuronal ceroid lipofuscinosis.
    1. Biochemistry and Chemical Biology

    Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans

    Yue Zhou et al.
    In response to starvation, C. elegans converts a favorable pheromone that induces aggregation to an unfavorable one that induces a stress-resistant larval stage, thereby altering its chemical message without having to synthesize new pheromones de novo.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity

    Pengxiang Fan et al.
    A nightshade family gene cluster creates phenotypic novelty in trichome defensive metabolites via evolution of lipid metabolic enzymes.

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