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A computer model of human cardiomyocyte was produced and validated on independent datasets, overcoming shortcomings of its predecessors, also yielding broadly relevant insights and results on major ionic currents.

Impairing TDP-43 RNA-binding capacity through a single acetylation-mimic mutation alters TDP-43 function and recapitulates biochemical, molecular, and behavioral features of sporadic TDP-43 proteinopathies, thus providing opportunities for new research into pathogenic mechanisms and therapeutic interventions.

The first structural and biochemical study of the role of the ATP-cone in anaerobic ribonucleotide reductases shows that dATP allosterically prevents transfer of a glycyl radical to the substrate.

Hybrid brain network models predict neurophysiological processes that link structural and functional empirical data across scales and modalities in order to better understand neural information processing and its relation to brain function.

In rodents and primates, there are two subtypes of parvalbumin-expressing interneurons that provide novel substrates for selective inhibition in the striatum.

The first born excitatory cerebellar nuclei neurons influence the survival of their Purkinje cell partners which stimulate the expansion of granule cells and interneurons to produce functional local circuits.

Sleep-encoded vocabulary influences awake decision-making 36 hr later, particularly when targeting the vocabulary to slow-wave troughs, which suggests that unconscious episodic memory formation during deep sleep is possible.