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    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Hsp70 chaperones are non-equilibrium machines that achieve ultra-affinity by energy consumption

    Paolo De Los Rios, Alessandro Barducci
    ATP consumption enables chaperones to exploit the different kinetic properties of their conformational states to exhibit a non-equilibrium affinity for their substrates that is orders of magnitude higher than its equilibrium value.
    1. Biochemistry and Chemical Biology

    Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing

    Jennifer L Fribourgh et al.
    The affinity of circadian repressors CRY1 and CRY2 for their cognate transcription factor CLOCK:BMAL1 is regulated by differential dynamics at the serine loop and interactions with the PER2 corepressor.
    1. Cancer Biology
    2. Cell Biology

    Different promoter affinities account for specificity in MYC-dependent gene regulation

    Francesca Lorenzin et al.
    Differences in promoter affinity and MYC levels explain distinct expression profiles induced by physiological and oncogenic MYC.
    1. Neuroscience

    A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones

    Matthias Siebert et al.
    High affinity interactions with transport adaptors are important to shield the interaction surfaces of cytomatrix components to block fatal premature oligomerization of active zone proteins during axonal transport.
    1. Cell Biology
    2. Immunology and Inflammation

    Small molecule inhibition of Csk alters affinity recognition by T cells

    Boryana N Manz et al.
    The T cell response, especially to weak agonists, is enhanced by acute Csk inhibition.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    MeCP2 nuclear dynamics in live neurons results from low and high affinity chromatin interactions

    Francesco M Piccolo et al.
    Single molecular imaging of MeCP2 at high spatial/temporal resolution identifies distinct structural domains contributing to its dynamic behaviors and chromatin interactions in live neurons.
    1. Computational and Systems Biology

    Building accurate sequence-to-affinity models from high-throughput in vitro protein-DNA binding data using FeatureREDUCE

    Todd R Riley et al.
    A biophysically principled algorithm can build quantitative models of protein-DNA binding specificity of unprecedented accuracy from a leading type of high-throughput in vitro binding data.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Mapping cell type-specific transcriptional enhancers using high affinity, lineage-specific Ep300 bioChIP-seq

    Pingzhu Zhou et al.
    A method for measuring p300 chromatin occupancy in specific lineages of mouse tissues was used to map endothelial enhancers and to identify previously unrecognized angiogenesis-related sequence motifs.
    1. Biochemistry and Chemical Biology

    Evolutionary and functional insights into the mechanism underlying body-size-related adaptation of mammalian hemoglobin

    Olga Rapp, Ofer Yifrach
    Hemoglobin affinity and cooperativity reveal mechanistic insights in how the relation between physiology and evolutionary variations shape a protein's molecular property.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis

    David Bolduc et al.
    C-terminal phosphorylation of the lipid phosphatase PTEN drives a reduction in membrane affinity and leads to a more compact conformation that involves a C2 domain-tail interaction.